国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
5期
499-502
,共4页
SLC11A1基因%结核病%易患性
SLC11A1基因%結覈病%易患性
SLC11A1기인%결핵병%역환성
SLC11A1 gene%Tuberculosis%Susceptibility
结核病是单一感染因素引起死亡人数最多的一种传染病.随着对结核病发病机制的深入研究,人们发现SLC11A1基因与结核病易患性有明显的相关性,其位于吞噬溶酶体膜上,通过改变细胞内环境,从而影响结核病的发生和发展.该文就SLC11M1基因作用机制及其与结核病易患性研究现状作一综述.
結覈病是單一感染因素引起死亡人數最多的一種傳染病.隨著對結覈病髮病機製的深入研究,人們髮現SLC11A1基因與結覈病易患性有明顯的相關性,其位于吞噬溶酶體膜上,通過改變細胞內環境,從而影響結覈病的髮生和髮展.該文就SLC11M1基因作用機製及其與結覈病易患性研究現狀作一綜述.
결핵병시단일감염인소인기사망인수최다적일충전염병.수착대결핵병발병궤제적심입연구,인문발현SLC11A1기인여결핵병역환성유명현적상관성,기위우탄서용매체막상,통과개변세포내배경,종이영향결핵병적발생화발전.해문취SLC11M1기인작용궤제급기여결핵병역환성연구현상작일종술.
Tuberculosis is the leading cause of death due to infection from a single microbial agent. With indepth study of the pathogenesis of tuberculosis,it was found that solute carrier family 11 member I gene SLC11A1) was ignificantly associated with susceptibility to tuberculosis. SLC11A1 is located in phagocytic lysosome membrane,influencing the occurrence and development of tuberculosis by changing the intracellular environment. In this paper, the mechanism of SLC11A1 gene and its relationwith susceptibility to tuberculosis are reviewed.
