CAJ | 학술논문

目的研究含钍稀土混合粉尘对职业暴露人员外周血淋巴细胞染色体畸变的影响.方法采用常规吉姆萨染色方法分析53名钍尘作业工人及58名非接尘工人(对照组)的染色体非稳定性畸变,荧光原位杂交方法分析10名钍尘作业工人及11名非接尘工人的染色体稳定性畸变.结果接尘组的畸变细胞、双着丝粒+环和总畸变率显著高于对照组(X2=4.12,P<0.05;X2=5.07,P<0.05;Y.=7.09,P<0.01).无着丝粒的畸变率在接尘组与对照组间差异无统计学意义.接尘组的易位率(4.5+-2.0)与对照组的易位率(3.8±1.7)比较差异无统计学意义(Z=-0.566,P>0.05).结论长期职业暴露于含钍稀土混合粉尘能够增加染色体的非稳定性畸变,未观察到易位率增加.
목적 연구함토희토혼합분진대직업폭로인원외주혈림파세포염색체기변적영향.방법 채용상규길모살염색방법분석53명토진작업공인급58명비접진공인(대조조)적염색체비은정성기변,형광원위잡교방법분석10명토진작업공인급11명비접진공인적염색체은정성기변.결과 접진조적기변세포、쌍착사립+배화총기변솔현저고우대조조(X2=4.12,P<0.05;X2=5.07,P<0.05;Y.=7.09,P<0.01).무착사립적기변솔재접진조여대조조간차이무통계학의의.접진조적역위솔(4.5+-2.0)여대조조적역위솔(3.8±1.7)비교차이무통계학의의(Z=-0.566,P>0.05).결론 장기직업폭로우함토희토혼합분진능구증가염색체적비은정성기변,미관찰도역위솔증가.
Objective To study the effect of thorium and rare earth mixed dust on chromosome aberrations in the lymphocytes of occupational exposed worker8.Methods Analyses of unstable chromosome aberrations on 53 occupational exposed worker8 and 58 control workers were carried out by the conventional Giemsa staining method.Fluorescence in situ hybridization method Wills performed to analyze the chromosome stable aberrations on 10 occupational exposed workers and 10 control workers.Results The frequencies of chromosomal aberration cells,dicentfics plus rings,total aberrations in exposed workers were significantly higher than those in controls.No significant difference was found in the frequency of acentric aberrations between exposed and non-exposed workers.No significant difference was found in the frequency of translocations between exposed and non-exposed workers.Conclusions Chronically occupational exposure to thorium and rare earthmixed dust can increase the induction of unstable chromosome aberration,but the increase of stable chromosome aberrations(translocation)can not be observed.