CAJ | 학술논문

目的分析新生儿B组溶血性链球菌败血症的临床特点及耐药性,为临床治疗提供依据.方法对2001年1月至2011年8月在我科住院治疗经血培养确诊的7例新生儿B组溶血性链球菌败血症患儿的临床资料、药物敏感试验结果进行回顾性分析.结果早发感染4例,晚发感染3例；白细胞减少6例,C反应蛋白升高6例,并发化脓性脑膜炎4例,感染性休克3例,弥散性血管内凝血2例.所有菌株对青霉素、万古霉素、利奈唑烷均敏感.结论应重视新生儿B组溶血性链球菌败血症,青霉素及万古霉素对该菌敏感性较高.
목적 분석신생인B조용혈성련구균패혈증적림상특점급내약성,위림상치료제공의거.방법 대2001년1월지2011년8월재아과주원치료경혈배양학진적7례신생인B조용혈성련구균패혈증환인적림상자료、약물민감시험결과진행회고성분석.결과 조발감염4례,만발감염3례；백세포감소6례,C반응단백승고6례,병발화농성뇌막염4례,감염성휴극3례,미산성혈관내응혈2례.소유균주대청매소、만고매소、리내서완균민감.결론 응중시신생인B조용혈성련구균패혈증,청매소급만고매소대해균민감성교고.
Objective To analyze the clinical characteristics and resistance of group B hemolytic streptococcus septicemia in neonates,and to provide the evidence for clinical treatment.Methods 7 neonates with group B hemolytic streptococcus septicemia hospitalized from Jan.2001 to Aug.2011 were enrolled in this study.The clinical data and laboratory results of antimicrobial sensitivity were analyzed retrospectively.Results There were 4 cases of early-onset infection and 3 cases of late-onset infection,6 cases with leukopenia,6 cases with c-reactive protein elevated,4 cases with suppurative meningitis,3 cases with septic shock and 2 cases with disseminated intravascular coagulation.All strains were sensitive to penicillin, vancomycin and linezolid.Conclusion Attention should be paid to neonatal group B hemolytic streptococcus septicemia.Penicillin and vancomycin are first choice for this type of infection.