中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
5期
510-513
,共4页
仇小强%贝春华%余红平%曾小云%钟秋安
仇小彊%貝春華%餘紅平%曾小雲%鐘鞦安
구소강%패춘화%여홍평%증소운%종추안
肝细胞癌%细胞因子%基因多态性
肝細胞癌%細胞因子%基因多態性
간세포암%세포인자%기인다태성
Hepatucellular carcinoma%Cytokine%Gene polymorphism
目的 探讨广西地区人群IL-6和IL-10基因单核苷酸多态性(SNP)与HBV相关肝癌的关系.方法 采用以医院为基础的病例对照研究方法,以381例肝癌患者为病例组,340例HBsAg携带者及359例健康体检者为对照组.应用荧光定量PCR对IL-6基因-572位点,IL-10基因-819和-592位点进行基因分型.采用非条件logistic回归模型分析比较携带不同基因型人群罹患肝癌的风险.结果 IL-6基因-572位点G/C等位基因在病例组、HBsAg携带组及健康对照组中分布差异有统计学意义(P＜0.05),与CC基因型相比,携带GG基因型个体慢性HBV感染危险性增加(OR=2.171,95%CI:1.068-4.415).IL-10基因-819位点T/C等位基因在三组的分布差异有统计学意义(P＜0.05),与CC基因型相比,携带TT基因型健康个体罹患肝癌的危险性增加(OR=2.791,95%CI:1.326～5.874).携带TT基因型的HBsAg携带者罹患肝癌的风险也增加(OR=3.522,95%CI:1.707～7.266).IL-10基因-592位点A/C等位基因在三组中的分布差异无统计学意义(P＞0.05),与CC基因型相比,携带AA基因型健康个体罹患肝癌的危险性降低(OR=0.389,95%CI:0.173-0.875),携带AA基因型的HBsAg携带者肝癌的罹患风险也降低(OR=0.336,95%CI:0.154-0.734).结论 IL-6基因-572位点SNP与广西地区人群慢性HBV感染有关,IL-10基因-819位点TT基因型个体罹患肝癌的风险增加,IL-592位点从基因型个体罹患肝癌的风险降低.
目的 探討廣西地區人群IL-6和IL-10基因單覈苷痠多態性(SNP)與HBV相關肝癌的關繫.方法 採用以醫院為基礎的病例對照研究方法,以381例肝癌患者為病例組,340例HBsAg攜帶者及359例健康體檢者為對照組.應用熒光定量PCR對IL-6基因-572位點,IL-10基因-819和-592位點進行基因分型.採用非條件logistic迴歸模型分析比較攜帶不同基因型人群罹患肝癌的風險.結果 IL-6基因-572位點G/C等位基因在病例組、HBsAg攜帶組及健康對照組中分佈差異有統計學意義(P＜0.05),與CC基因型相比,攜帶GG基因型箇體慢性HBV感染危險性增加(OR=2.171,95%CI:1.068-4.415).IL-10基因-819位點T/C等位基因在三組的分佈差異有統計學意義(P＜0.05),與CC基因型相比,攜帶TT基因型健康箇體罹患肝癌的危險性增加(OR=2.791,95%CI:1.326～5.874).攜帶TT基因型的HBsAg攜帶者罹患肝癌的風險也增加(OR=3.522,95%CI:1.707～7.266).IL-10基因-592位點A/C等位基因在三組中的分佈差異無統計學意義(P＞0.05),與CC基因型相比,攜帶AA基因型健康箇體罹患肝癌的危險性降低(OR=0.389,95%CI:0.173-0.875),攜帶AA基因型的HBsAg攜帶者肝癌的罹患風險也降低(OR=0.336,95%CI:0.154-0.734).結論 IL-6基因-572位點SNP與廣西地區人群慢性HBV感染有關,IL-10基因-819位點TT基因型箇體罹患肝癌的風險增加,IL-592位點從基因型箇體罹患肝癌的風險降低.
목적 탐토엄서지구인군IL-6화IL-10기인단핵감산다태성(SNP)여HBV상관간암적관계.방법 채용이의원위기출적병례대조연구방법,이381례간암환자위병례조,340례HBsAg휴대자급359례건강체검자위대조조.응용형광정량PCR대IL-6기인-572위점,IL-10기인-819화-592위점진행기인분형.채용비조건logistic회귀모형분석비교휴대불동기인형인군리환간암적풍험.결과 IL-6기인-572위점G/C등위기인재병례조、HBsAg휴대조급건강대조조중분포차이유통계학의의(P＜0.05),여CC기인형상비,휴대GG기인형개체만성HBV감염위험성증가(OR=2.171,95%CI:1.068-4.415).IL-10기인-819위점T/C등위기인재삼조적분포차이유통계학의의(P＜0.05),여CC기인형상비,휴대TT기인형건강개체리환간암적위험성증가(OR=2.791,95%CI:1.326～5.874).휴대TT기인형적HBsAg휴대자리환간암적풍험야증가(OR=3.522,95%CI:1.707～7.266).IL-10기인-592위점A/C등위기인재삼조중적분포차이무통계학의의(P＞0.05),여CC기인형상비,휴대AA기인형건강개체리환간암적위험성강저(OR=0.389,95%CI:0.173-0.875),휴대AA기인형적HBsAg휴대자간암적리환풍험야강저(OR=0.336,95%CI:0.154-0.734).결론 IL-6기인-572위점SNP여엄서지구인군만성HBV감염유관,IL-10기인-819위점TT기인형개체리환간암적풍험증가,IL-592위점종기인형개체리환간암적풍험강저.
Objective To investigate the association between single nucleotide polymorphisms (SNPs)in cytokine IL-6, IL- 10 genes and HBV-related hepatocellular carcinoma(HCC). Methods A hospital-based case-control study was conducted in 381 cases with HBV-related HCC, 340 HBsAg carriers and 359 non-tumor controls. Genotypes of-572 site of IL-6 gene and-819, -592 sites of IL-10 gene were determined by real-time polymorphism chain reaction. Unconditional logistic regression was used to estimate the odds ratios(ORs)and 95 confidence intervals(C/s). Results For the G/C alleles of -572 loci on IL-6 gene, there were significant differences between the three groups(P＜0.05). Compared with CC genotype, GG genotype increased the risk of HBV infection (OR=2.171,95% Ch 1.068-4.415), but did not seem to be associated with HCC. For the alleles of-819 and -592 site of IL-10 gene, there were significant differences between the three groups(P＜0.05). Compared with CC genotype, TT genotype increased the risks of both HCC(OR=2.791,95%CI:1.326-5.874), and HCC in HBsAg carriers(0R=3.522,95%CI: 1.707-7.266). When compared with CC genotype on -592 site, the AA genotype reduced the risk of both HCC(OR=0.389, 95% CI:0.173-0.875), and HCC in HBsAg carriers(OR=0.336, 95% CI: 0.154-0.734). Conclusion The SNPs in -572 site of IL-6 gone might be associated with the risk of HBV infection. The SNPs in -819 site of IL-10 gene increased the risk of HCC, but -592 site of IL-10 gene decreased the risk of HCC.
