CAJ | 학술논문

既往研究已表明谷胱甘肽S-转肽酶(GSTs)存在基因多态性,这种突变可增加人体对癌源性物质及炎症性疾病的敏感性.近年的研究结果提示GSTs基因多态性与动脉粥样硬化密切相关,这种相关性使我们从分子水平上探讨动脉粥样硬化的发病机制,从而达到基于个体基因型采取预防及治疗措施.
기왕연구이표명곡광감태S-전태매(GSTs)존재기인다태성,저충돌변가증가인체대암원성물질급염증성질병적민감성.근년적연구결과제시GSTs기인다태성여동맥죽양경화밀절상관,저충상관성사아문종분자수평상탐토동맥죽양경화적발병궤제,종이체도기우개체기인형채취예방급치료조시.
Glutathione S-transferase gene exhibits genetic polymorphisms, and this variation can in-crease the susceptibility to carcinogenesis and inflammatory disease. Recent research suggests the gene polymor-phism of ghitathione S-transferase is associated with atherosclerosis. The study of this relationship and consider-ation of the molecular aspects of the causes of atherosclerosis should lead to new approaches to the prevention and clinical treatment of atherosclerosis according to individual genotypes.