CAJ | 학술논문

Ku是由Ku70和Ku80两个亚基组成的异质二聚体蛋白,它与DNA依赖蛋白激酶催化亚单位(DNA-PKcs)共同组成DNA依赖的蛋白激酶.射线杀伤肿瘤细胞主要通过破坏DNA双链,导致DNA损伤不能修复,从而引起细胞凋亡.Ku蛋白是DNA损伤修复中的关键因子,通过阻断Ku蛋白能够增加肿瘤细胞的放射敏感性.
Ku시유Ku70화Ku80량개아기조성적이질이취체단백,타여DNA의뢰단백격매최화아단위(DNA-PKcs)공동조성DNA의뢰적단백격매.사선살상종류세포주요통과파배DNA쌍련,도치DNA손상불능수복,종이인기세포조망.Ku단백시DNA손상수복중적관건인자,통과조단Ku단백능구증가종류세포적방사민감성.
Ku is a heterodimeric protein which is composed of Ku70 and Ku80.DNA dependent protein kinase is composed of Ku and DNA dependent protein kinase catalytic subunit (DNA-PKcs).DNA double strands break is the main method that radiation kill tumor cell,which will restraint DNA repair,and induce cell apoptosis.Ku protein is the key point in the repair of DNA.Blocking Ku protein will increase the radiosensitivity of tumor cell.