中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2011年
4期
299-302
,共4页
郑艳%丁军%王春利%焦守山%曲利明%巴哈尔古丽%包辉%陈晓
鄭豔%丁軍%王春利%焦守山%麯利明%巴哈爾古麗%包輝%陳曉
정염%정군%왕춘리%초수산%곡리명%파합이고려%포휘%진효
癌,鳞状细胞%鼻肿瘤%基质金属蛋白酶2%基质金属蛋白酶9%金属蛋白酶1组织抑制剂%金属蛋白酶2组织抑制剂
癌,鱗狀細胞%鼻腫瘤%基質金屬蛋白酶2%基質金屬蛋白酶9%金屬蛋白酶1組織抑製劑%金屬蛋白酶2組織抑製劑
암,린상세포%비종류%기질금속단백매2%기질금속단백매9%금속단백매1조직억제제%금속단백매2조직억제제
Carcinoma,squamous cell%Nose neoplasms%Matrix metalloproteinase2%Matrix metalloproteinase 9%Tissue inhibitor of metalloproteinase-1%Tissue inhibitor of metalloproteinase-2
目的 研究基质金属蛋白酶(matrix metalloproteinase,MMP)2、MMP-9及组织金属蛋白酶抑制剂(tissue inhibitor of metalloproteinase,TIMP)1、TIMP-2在鼻腔鳞状细胞癌中的表达及意义.方法 应用免疫组化S-P法检测50例鼻腔鳞状细胞癌和50例中鼻甲或下鼻甲组织中MMP-2、MMP-9、TIMP-1和TIMP-2的表达,并分析它们的表达与临床病理结果间的关系.以SPSS 12.0软件对数据进行统计学分析.结果 鼻腔鳞状细胞癌组织和中鼻甲或下鼻甲组织中MMP-2阳性表达检出率分别为52.0%(26/50)、28.0%(14/50),差异有统计学意义(x2=6.00,P＜0.05);MMP-9阳性表达检出率分别为58.0%(29/50)、10.0%(5/50),差异有统计学意义(x2=12.80,P＜0.05);TIMP-1阳性表达检出率分别为74.0%(37/50)、56.0%(28/50),差异无统计学意义(x2=0.51,P＞0.05);TIMP-2阳性表达检出率分别为26.0%(13/50)、20.0%(10/50),差异无统计学意义(x2=3.35,P＞0.05).结论 鼻腔鳞状细胞癌的发生、发展与MMP-2、MMP-9表达有关系,MMP与TIMP比例失衡在判断鼻腔鳞状细胞癌侵袭性及预后中可能有一定意义.
目的 研究基質金屬蛋白酶(matrix metalloproteinase,MMP)2、MMP-9及組織金屬蛋白酶抑製劑(tissue inhibitor of metalloproteinase,TIMP)1、TIMP-2在鼻腔鱗狀細胞癌中的錶達及意義.方法 應用免疫組化S-P法檢測50例鼻腔鱗狀細胞癌和50例中鼻甲或下鼻甲組織中MMP-2、MMP-9、TIMP-1和TIMP-2的錶達,併分析它們的錶達與臨床病理結果間的關繫.以SPSS 12.0軟件對數據進行統計學分析.結果 鼻腔鱗狀細胞癌組織和中鼻甲或下鼻甲組織中MMP-2暘性錶達檢齣率分彆為52.0%(26/50)、28.0%(14/50),差異有統計學意義(x2=6.00,P＜0.05);MMP-9暘性錶達檢齣率分彆為58.0%(29/50)、10.0%(5/50),差異有統計學意義(x2=12.80,P＜0.05);TIMP-1暘性錶達檢齣率分彆為74.0%(37/50)、56.0%(28/50),差異無統計學意義(x2=0.51,P＞0.05);TIMP-2暘性錶達檢齣率分彆為26.0%(13/50)、20.0%(10/50),差異無統計學意義(x2=3.35,P＞0.05).結論 鼻腔鱗狀細胞癌的髮生、髮展與MMP-2、MMP-9錶達有關繫,MMP與TIMP比例失衡在判斷鼻腔鱗狀細胞癌侵襲性及預後中可能有一定意義.
목적 연구기질금속단백매(matrix metalloproteinase,MMP)2、MMP-9급조직금속단백매억제제(tissue inhibitor of metalloproteinase,TIMP)1、TIMP-2재비강린상세포암중적표체급의의.방법 응용면역조화S-P법검측50례비강린상세포암화50례중비갑혹하비갑조직중MMP-2、MMP-9、TIMP-1화TIMP-2적표체,병분석타문적표체여림상병리결과간적관계.이SPSS 12.0연건대수거진행통계학분석.결과 비강린상세포암조직화중비갑혹하비갑조직중MMP-2양성표체검출솔분별위52.0%(26/50)、28.0%(14/50),차이유통계학의의(x2=6.00,P＜0.05);MMP-9양성표체검출솔분별위58.0%(29/50)、10.0%(5/50),차이유통계학의의(x2=12.80,P＜0.05);TIMP-1양성표체검출솔분별위74.0%(37/50)、56.0%(28/50),차이무통계학의의(x2=0.51,P＞0.05);TIMP-2양성표체검출솔분별위26.0%(13/50)、20.0%(10/50),차이무통계학의의(x2=3.35,P＞0.05).결론 비강린상세포암적발생、발전여MMP-2、MMP-9표체유관계,MMP여TIMP비례실형재판단비강린상세포암침습성급예후중가능유일정의의.
Objective To study the expression and significance of matrix metalloproteinase (MMP)2, MMP-9, tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP-2 in nasal cavity squamous cell carcinoma and their signification. Methods Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasal tissue were detected for MMP-2, MMP-9, TIMP-1, TIMP-2 by immunohistochemistry technique (S-P), and their relationship between the expression of MMP-2, MMP-9, TIMP-1, TIMP-2 and some clinical symptoms were analyzed. The SPSS 12. 0 software was used to analyze the data. Results The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52. 0% (26/50), which was significantly higher ( x2 = 6. 00, P ＜0. 05 ) than those [28.0% (14/50)] in the normal nasal tissue. The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0% (29/50), which was significantly higher ( x2 = 12. 8, P ＜ 0. 05 ) than those [10. 0% (5/50)] in the normal nasal tissue. The positive ratio of expression of TIMP-1 in two groups was 74. 0% (37/50), 56. 0% (28/50) respectively.There was no difference between two groups ( x2 = 0. 51, P ＞ 0. 05 ). The positive ratio of expression of TIMP-2 in two groups was 26. 0% ( 13/50), 20% (10/50) respectively. There was no difference between two groups( x2 = 3.35, P ＞ 0. 05). Conclusions There was a close relationship between pathogenesis and development of nasal epithelial carcinoma and the expression of MMP-2, MMP-9 in the epithelial carcinoma tissues. Both MMP and TIMP, especially the unbalance of MMP and TIMP, have prognostic value in nasal cavity squamous cell carcinoma.
