中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
8期
37-39
,共3页
替罗非班%不稳定型心绞痛%心血管事件
替囉非班%不穩定型心絞痛%心血管事件
체라비반%불은정형심교통%심혈관사건
Tirofiban%Unstable angina pectoris%Cardiovascular events
目的 评价替罗非班对不稳定型心绞痛(UAP)患者疗效和近期心血管事件发生率的影响.方法 将78例UAP患者随机分为观察组40例和对照组38例,对照组采用常规抗凝治疗(阿司匹林＋低分子肝素＋氯吡格雷),观察组在对照组治疗的基础上加用替罗非班静脉持续点滴72 h.治疗7 d后观察心绞痛控制情况,治疗30 d统计近期心血管事件发生率.结果 治疗后7 d观察组的总有效率显效率、显著高于对照组(χ2=4.9673,P＜0.05),治疗后30 d观察组心血管事件的发生率显著低于对照组(χ2=3.9209,P＜0.01),两组30 d内不良反应的发生率比较差异无统计学意义(P＞0.05).结论 在常规抗凝治疗的基础上加用替罗非班治疗不稳定型心绞痛能进一步获益,更加有效地控制心绞痛,减少不良心血管事件的发生,且不增加严重出血的发生.
目的 評價替囉非班對不穩定型心絞痛(UAP)患者療效和近期心血管事件髮生率的影響.方法 將78例UAP患者隨機分為觀察組40例和對照組38例,對照組採用常規抗凝治療(阿司匹林＋低分子肝素＋氯吡格雷),觀察組在對照組治療的基礎上加用替囉非班靜脈持續點滴72 h.治療7 d後觀察心絞痛控製情況,治療30 d統計近期心血管事件髮生率.結果 治療後7 d觀察組的總有效率顯效率、顯著高于對照組(χ2=4.9673,P＜0.05),治療後30 d觀察組心血管事件的髮生率顯著低于對照組(χ2=3.9209,P＜0.01),兩組30 d內不良反應的髮生率比較差異無統計學意義(P＞0.05).結論 在常規抗凝治療的基礎上加用替囉非班治療不穩定型心絞痛能進一步穫益,更加有效地控製心絞痛,減少不良心血管事件的髮生,且不增加嚴重齣血的髮生.
목적 평개체라비반대불은정형심교통(UAP)환자료효화근기심혈관사건발생솔적영향.방법 장78례UAP환자수궤분위관찰조40례화대조조38례,대조조채용상규항응치료(아사필림＋저분자간소＋록필격뢰),관찰조재대조조치료적기출상가용체라비반정맥지속점적72 h.치료7 d후관찰심교통공제정황,치료30 d통계근기심혈관사건발생솔.결과 치료후7 d관찰조적총유효솔현효솔、현저고우대조조(χ2=4.9673,P＜0.05),치료후30 d관찰조심혈관사건적발생솔현저저우대조조(χ2=3.9209,P＜0.01),량조30 d내불량반응적발생솔비교차이무통계학의의(P＞0.05).결론 재상규항응치료적기출상가용체라비반치료불은정형심교통능진일보획익,경가유효지공제심교통,감소불양심혈관사건적발생,차불증가엄중출혈적발생.
Objective To evaluate the influence of tirofiban on effect and recent incidence of cardiovascular events in patients with unstable angina pectoris.Methods Seventy-eight patients with UAP were randomly divided into observation group (40 cases) and control group(38 cases),the patients in control group took conventional anticoagulation therapy (low molecular weight heparin+aspirin+clopidogrel),the patients in the observation group were treated additionally with continuous intravenous tirofiban drip 72 h based on the control group.To observe angina pectoris control situation after 7 days,to statistical the recent incidence of cardiovascular events after 30 days.Results After 7 days,the total efficiency of the observation group was significantly higher than that of the control group (χ2=4.9673,P<0.05).After 30 days,the cardiac events in the observation group were significantly lower than the control group (χ2=3.9209,P<0.01).The incidence of cardiovascular reactions in the two groups was no significant difference within 30 days (P＞0.05).Conclusions It can further benefit from additional treatment with tirofiban in unstable angina on the basis of conventional anticoagulation therapy,and more effective control of angina,reduce the incidence of adverse cardiovascular events and does not increase the incidence of serious bleeding.
