CAJ | 학술논문

目的探讨影响平均血小板体积(MPV)的危险因素并分析MPV与糖尿病下肢动脉病变的相关关系.方法纳入研究对象173例,2型糖尿病91例、糖调节受损(IGR)41例和正常糖耐量(NGT)人群41名,测量收缩压、舒张压,甘油三酯、胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇( LDL-C)、空腹血糖(FPG)、血肌酐、血小板计数以及MPV,体重、身高,并计算体质指数.糖尿病患者测量糖化血红蛋白(HbA1c)及其踝肱指数.结果 (1)2型糖尿病患者MPV最高,为(12.3±1.5)fl,高于IGR (9.7±0.9) fl和NGT者(8.0±0.9) fl(P ＜0.01)；在糖尿病患者中,HbA1c≥7％的患者MPV(13.2±1.9)fl明显高于HbA1c＜7％的患者(11.8±1.7) fl(P＜0.01)；(2)多元逐步回归分析显示,患者年龄、血肌酐、LDL-C和FPG水平是影响MPV的重要危险因素,调整R2 =0.891；(3)非条件Logistic回归分析显示MPV(OR=1.648,P=0.042)是周围动脉病变发生的危险因素.结论年龄、血肌酐、LDL-C和FPG水平是MPV的重要影响因素；MPV是周围动脉病变发生的危险因素.
목적 탐토영향평균혈소판체적(MPV)적위험인소병분석MPV여당뇨병하지동맥병변적상관관계.방법 납입연구대상173례,2형당뇨병91례、당조절수손(IGR)41례화정상당내량(NGT)인군41명,측량수축압、서장압,감유삼지、담고순、고밀도지단백담고순、저밀도지단백담고순( LDL-C)、공복혈당(FPG)、혈기항、혈소판계수이급MPV,체중、신고,병계산체질지수.당뇨병환자측량당화혈홍단백(HbA1c)급기과굉지수.결과 (1)2형당뇨병환자MPV최고,위(12.3±1.5)fl,고우IGR (9.7±0.9) fl화NGT자(8.0±0.9) fl(P ＜0.01)；재당뇨병환자중,HbA1c≥7％적환자MPV(13.2±1.9)fl명현고우HbA1c＜7％적환자(11.8±1.7) fl(P＜0.01)；(2)다원축보회귀분석현시,환자년령、혈기항、LDL-C화FPG수평시영향MPV적중요위험인소,조정R2 =0.891；(3)비조건Logistic회귀분석현시MPV(OR=1.648,P=0.042)시주위동맥병변발생적위험인소.결론 년령、혈기항、LDL-C화FPG수평시MPV적중요영향인소；MPV시주위동맥병변발생적위험인소.
Objective To explore the variance of mean platelet volume (MPV) in subjects with normal glucose tolerance (NGT),impaired glucose regulation (IGR) and type 2 diabetes mellitus (T2DM) and risk factors of MPV changes and analyze the relationship between MPV and diabetic peripheral artery disease (PAD). Methods A total of 173 subjects were enrolled into this observational cross-sectional study.They were divided into 3 groups: NGT (n =41),IGR (n =41) and T2DM (n=91). Blood pressure (BP),platelet count (PLT),mean platelet volume (MPV) and such fasting serum lipids as triglycerides (TG),total cholesterol ( TC ),high density lipoprotein ( HDL-C),low density lipoprotein (LDL-C),fast plasma glucose (FPG) and serum uric acid (UA) were determined.HbA1c and ankle/brachial index (ABI) were also measured.Results ( 1 ) The MPV level was highest in the T2DM group ( 12.3 ± 1.5 ) fl.And it was significantly higher in the IGR group than in the NGT group (9.7 ± 0.9 vs 8.0 ±0.9) fl (P ＜0.01 ).It was significantly higher in diabetics with HbA1c≥7％ ( 13.2 ± 1.9) fl than in patients those with HbA1c 7％ ( 11.8 ± 1.7 ) fl ( P ＜ 0.0 1 ) ; ( 2 ) Stepwise multiple regression analysis showed that age,serum creatinine,LDL-C and fasting plasma glucose (FPG) were important influencing factors of MPV (adjusted R2 =0.891 ) ; (3) Multiple Logistic regression analysis indicated that MPV was an important risk factor of PAD.Conclusion The MPV level in T2DM is significantly higher than that in NGT and IGR subjects.FPG,LDL-C,age and serum creatinine are important contributors to MPV.And MPV is an important risk factor of PAD.