生殖医学杂志
生殖醫學雜誌
생식의학잡지
JOURNAL OF REPRODUCTIVE MEDICINE
2003年
z1期
47-50
,共4页
王一峰%韩兰英%欧汝强%杨宁%谢端薇%陈巧儿
王一峰%韓蘭英%歐汝彊%楊寧%謝耑薇%陳巧兒
왕일봉%한란영%구여강%양저%사단미%진교인
Premature ovarian failure%Anti-zona pellucida antibody%Tumornecrosis factor-α%Interferon-γ%Interleukin-2
Objective:To investigate the role and the clinical significance of anti-zona pellucidaantibody (AzpAb) and tumor necrosis factor-α(TNF-α),γ-interferon(IFN-γ) and inter-leukin-2 (IL-2) in sera from patients with premature ovarian failure (POF).Methods: The AzpAb in the serum of POF patient was analyzed by means ofELISA. The levels of TNF-α, IL-2 and IFN-γ in the serum were determined by meansof radioimmunoassay (RIA).Results:The level of serum AzpAb in the POF patients was significantly higher thanthat of the normal controls(P＜0.001). The levels of TNF-α and IL-2 were significantlyreduced (P＜0. 001), and the level of IFN-γ was significantly elevated (P＜0.01). Thelevels of above three cytokines in AzpAb positive group were significantly higher thanthose of the negative group in POF patients.Conclusion: This study suggested that AzpAb, TNF-α, IFN-γ and IL-2 might playimportant roles in the pathogenesis of autoimmune POF.
