CAJ | 학술논문

目的探讨2型糖尿病(T2DM)患者脂代谢紊乱状态下过氧化物酶体脂肪酸β氧化活性的变化.方法分析112例T2DM患者外周血单个核细胞过氧化物酶体脂肪酸β氧化活性、脂肪乙酰辅酶A氧化酶活性及其mRNA表达变化.测定FPG、 TC、 TG、 HDC、 LDL-C.结果 T2DM患者过氧化物酶体脂肪酸β氧化代偿性加强,与正常对照组相比,脂肪乙酰辅酶A氧化酶活性、过氧化物酶体脂肪酸β氧化活性增加;并且T2DM组过氧化物酶体脂肪酸β氧化的活性与其血清TG、 HDL-C、 LDL-C之间有直线相关关系.结论脂肪酸β氧化和脂肪乙酰辅酶A氧化酶的活性增加,导致H2O2浓度的升高,这可能是糖尿病心血管并发症发病的原因之一.
목적 탐토2형당뇨병(T2DM)환자지대사문란상태하과양화물매체지방산β양화활성적변화.방법 분석112례T2DM환자외주혈단개핵세포과양화물매체지방산β양화활성、지방을선보매A양화매활성급기mRNA표체변화.측정FPG、 TC、 TG、 HDC、 LDL-C.결과 T2DM환자과양화물매체지방산β양화대상성가강,여정상대조조상비,지방을선보매A양화매활성、과양화물매체지방산β양화활성증가;병차T2DM조과양화물매체지방산β양화적활성여기혈청TG、 HDL-C、 LDL-C지간유직선상관관계.결론 지방산β양화화지방을선보매A양화매적활성증가,도치H2O2농도적승고,저가능시당뇨병심혈관병발증발병적원인지일.
Objective To explore the change of the activities of peroxisome β-oxidation in T2DM patients with the lipid disorders.Methods We analyzed the changes of the activities of peroxisome β-oxidation and fatty acyl-CoA oxidase and its mRNA expression in 112 cases of T2DM patients.Results We found that there was compensatory increase in activity of peroxisome β-oxidation of T2DM patients.As compared with control group,the activity of fatty acyl-CoA oxidase of T2DM group was increased by 5%(P<0.05),the activity of peroxisome β-oxidation was increased by 37%(P<0.05),There were linear correlations of theof peroxisomal β-oxidation with serum TG,HDL,and LDL.Conclusions The increase of the activities of peroxisomal β-oxidation and fatty acyl-CoA oxidase leads the increase of H2O2 concentration.This may be one of the causes of T2DM cardiovascular complications