中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2010年
2期
396-400
,共5页
王广鹤%许海燕%陈瑞瑞%何德富
王廣鶴%許海燕%陳瑞瑞%何德富
왕엄학%허해연%진서서%하덕부
帕金森病%苍白球%多巴胺%谷氨酸
帕金森病%蒼白毬%多巴胺%穀氨痠
파금삼병%창백구%다파알%곡안산
Parkinson disease%Globus pallidus%Dopamine%Glutamic acid
As an important nucleus of basal ganglia, globus pallidus was concerned to involve in the neural mechanism of Parkins's disease (PD). Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons, the balance between inhibition and excitation is broken in the output nuclei of basal ganglia, and globus pallidus neurons display bursting and oscillatory discharge, the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms, such as bradykinesia, rigidity and tremor, which reflects that globus pallidus plays an important role in the process of PD. In the present paper, the recent advances in pathophysiology in globus pallidus, its clinical application in treatment of Parkinson's disease, and the study direction in the future are reviewed.
