国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2009年
13期
777-779
,共3页
慢性阻塞性肺疾病%乌司他丁%肿瘤坏死因子α%白介素8
慢性阻塞性肺疾病%烏司他丁%腫瘤壞死因子α%白介素8
만성조새성폐질병%오사타정%종류배사인자α%백개소8
Chronic obstructive pulmonary disease%Ulinastatin%TNF-α%IL-8
目的 探讨乌司他丁治疗慢性阻塞性肺疾病急性加重期的临床疗效和部分作用机制.方法 对符合慢性阻塞性肺疾病急性加重期诊断标准的72例患者,随机分为乌司他丁治疗组和对照组,各36例,两组均予常规治疗,治疗组在此基础上加用乌司他丁20万U,静脉注射,3次/d,连用7 d.结果 治疗组总有效率为86.11%,明显优于对照组69.44%(P<0.05),治疗组在改善APACHEⅡ评分、血气分析方面明显优于对照组,且能显著降低C反应蛋白、肿瘤坏死因子α、白介素8含量,明显缩短患者机械通气及入住重症监护病房时间(P<0.05).结论 慢性阻塞性肺疾病急性加重期在常规治疗的基础上加用乌司他丁有较好的临床疗效,其作用机制可能在于通过抑制炎症介质和细胞因子的释放,减轻炎症反应,舒张平滑肌、改善患者的通气功能和血液流变学指标.
目的 探討烏司他丁治療慢性阻塞性肺疾病急性加重期的臨床療效和部分作用機製.方法 對符閤慢性阻塞性肺疾病急性加重期診斷標準的72例患者,隨機分為烏司他丁治療組和對照組,各36例,兩組均予常規治療,治療組在此基礎上加用烏司他丁20萬U,靜脈註射,3次/d,連用7 d.結果 治療組總有效率為86.11%,明顯優于對照組69.44%(P<0.05),治療組在改善APACHEⅡ評分、血氣分析方麵明顯優于對照組,且能顯著降低C反應蛋白、腫瘤壞死因子α、白介素8含量,明顯縮短患者機械通氣及入住重癥鑑護病房時間(P<0.05).結論 慢性阻塞性肺疾病急性加重期在常規治療的基礎上加用烏司他丁有較好的臨床療效,其作用機製可能在于通過抑製炎癥介質和細胞因子的釋放,減輕炎癥反應,舒張平滑肌、改善患者的通氣功能和血液流變學指標.
목적 탐토오사타정치료만성조새성폐질병급성가중기적림상료효화부분작용궤제.방법 대부합만성조새성폐질병급성가중기진단표준적72례환자,수궤분위오사타정치료조화대조조,각36례,량조균여상규치료,치료조재차기출상가용오사타정20만U,정맥주사,3차/d,련용7 d.결과 치료조총유효솔위86.11%,명현우우대조조69.44%(P<0.05),치료조재개선APACHEⅡ평분、혈기분석방면명현우우대조조,차능현저강저C반응단백、종류배사인자α、백개소8함량,명현축단환자궤계통기급입주중증감호병방시간(P<0.05).결론 만성조새성폐질병급성가중기재상규치료적기출상가용오사타정유교호적림상료효,기작용궤제가능재우통과억제염증개질화세포인자적석방,감경염증반응,서장평활기、개선환자적통기공능화혈액류변학지표.
Objective To discuss the effect of ulinastatin on chronic obstructive pulmonary disease with acute exacerbation and part of the mechanism. Methods Seventy-two cases consistent with the diagnostic criteria were randomly divided into ulinastatin statin therapy group and control group (36 cases each group),two groups both received conventional treatment,the treatment group on this basis was added ulinastatin with 200 000 U,intravenous injection, three times a day. Results In the treatment group the total effective rate was 86.11%, significantly better than in the control group 69.44% (P<0.05), its improvement in APACHE Ⅱ score,blood gas analysis and reduction in CRP,TNF-α,IL-8 was superior to the control group. The treatment group was significantly shorter than the control group in mechanical ventilation and ICU stay time (P<0.05). Conclusions Conventional therapy as basis plus ulinastatin has better clinical efficacy,for whose chronic obstructive pulmonary disease with acute exacerbation mechanism may lie in the inhibition of inflammatory mediators and cytokines release, reducing inflammation, relaxing smooth muscle,improving the patient's ventilatory function and blood rheotogy.
