CAJ | 학술논문

目的探讨10 kd低分子量尿蛋白在原发性肾小球疾病患者中临床病理的意义.方法对本院120例临床、病理证实为原发性肾小球疾病患者.检测尿常规、24 h尿蛋白定量、血肌酐等,计算肾小球滤过率;Katafuchi R半定量标准对肾小管间质病理进行评分;薄层十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)检测患者尿蛋白分子量,以是否含有10 kd低分子量尿蛋白分为2组,比较分析其临床病理差异.结果含有10 kd低分子量尿蛋白患者38例,同82例不含10 kd尿蛋白患者相比,血肌酐较高[(185.63±123.29)μmol/L vs(84.92±60.31)μmol/L,P＞0.05],肾小球滤过率较低[(40.6±18.3)ml·(min·1.73m2)-1 vs(79.8±30.6)ml·(min·1.73m2)-1,p＞0.05],肾间质病理评分较高(5.9±3.7 vs 3.3±2.1,p＞0.05);两组间差异有统计学意义.结论出现10 kd低分子量尿蛋白患者临床病理表现均较严重,预后较差.10kd低分子量尿蛋白对患者慢性肾脏病的进展起重要作用.
목적 탐토10 kd저분자량뇨단백재원발성신소구질병환자중림상병리적의의.방법 대본원120례림상、병리증실위원발성신소구질병환자.검측뇨상규、24 h뇨단백정량、혈기항등,계산신소구려과솔;Katafuchi R반정량표준대신소관간질병리진행평분;박층십이완기류산납-취병희선알응효전영(SDS-PAGE)검측환자뇨단백분자량,이시부함유10 kd저분자량뇨단백분위2조,비교분석기림상병리차이.결과 함유10 kd저분자량뇨단백환자38례,동82례불함10 kd뇨단백환자상비,혈기항교고[(185.63±123.29)μmol/L vs(84.92±60.31)μmol/L,P＞0.05],신소구려과솔교저[(40.6±18.3)ml·(min·1.73m2)-1 vs(79.8±30.6)ml·(min·1.73m2)-1,p＞0.05],신간질병리평분교고(5.9±3.7 vs 3.3±2.1,p＞0.05);량조간차이유통계학의의.결론 출현10 kd저분자량뇨단백환자림상병리표현균교엄중,예후교차.10kd저분자량뇨단백대환자만성신장병적진전기중요작용.
Objectives To investigate the clinicopathologic significance of urinary protein of 10kd low molecular weight in primary glomerulopathy. Methods The serum creatinine levels(Scr) ,24h urine protein quantitation and glomerular filtration rate(GFR) were measured and the score s of tubulointerstitial lesions were examined by Katafuchi R standard in 120 biopsy-proven cases of primary glomerulopathy patients. Urine protein was analyzed by thin- membrane sodium dodecyl sulphat-polyacrylamide gel electrophoresis( SDS-PAGE). The clinicopathologic characteristics between the patients with and without urinary protein of 10kd low molecular weight were compared.Results Amongst the 120 patients studied ,38 had urinary protein of 10kd low molecular weight, compared with other 82 cases without 10kd urinary protein ,the 5cr was higher [ ( 185.63 ± 123.29 ) μ mol/L vs ( 84.92 ± 60.31 )73 m2 )-1 vs ( 79.8 ± 30.6 ) ml/min/1. 73 m2, p ＞ 0. 05 ], the score of tubulointerstitial lesions was higher( 5.9 ± 3.7 vs 3.3 ± 2. 1, p ＞ 0.05 ), the differences had statistical significance. Conclusions The patients with urinary protein of 10kd have a poorer prognosis than those patients without. Urinary protein of 10kd low molecular weight plays an important role in the progression of chronic kidney disease.