CAJ | 학술논문

皮质脊髓束Waller变性是由于其上运动神经元或轴突损伤引起的远端轴突和髓鞘顺行性变性.卒中是引起皮质脊髓束Waller变性的最常见原因.皮质脊髓束Waller变性的常规MRI显示为与原发病灶相连的符合皮质脊髓束走行的条状异常信号,但常规MRI无法显示卒中发生后4周内的Waller变性.MRI弥散张量成像(diffusion tensor imaging,DTI)可早期检测皮质脊髓束Waller变性,且可动态观察从亚急性早期到慢性期的病理变化过程.文章综述了DTI在显示卒中后皮质脊髓束Waller变性,尤其是早期Waller变性中的作用,以及在卒中患者预后判断和后期康复中的价值.
피질척수속Waller변성시유우기상운동신경원혹축돌손상인기적원단축돌화수초순행성변성.졸중시인기피질척수속Waller변성적최상견원인.피질척수속Waller변성적상규MRI현시위여원발병조상련적부합피질척수속주행적조상이상신호,단상규MRI무법현시졸중발생후4주내적Waller변성.MRI미산장량성상(diffusion tensor imaging,DTI)가조기검측피질척수속Waller변성,차가동태관찰종아급성조기도만성기적병리변화과정.문장종술료DTI재현시졸중후피질척수속Waller변성,우기시조기Waller변성중적작용,이급재졸중환자예후판단화후기강복중적개치.
Wallerian degeneration of the corticospinal tracts is the anterograde degener-ation of distal axons and myelin caused by the upper motor neuron injury or axonal injury.Stroke is the most common cause of Wallerian degeneration of the corticospinal tracts. Conventional magnetic resonance imaging (MRI) of Wallerian degeneration of the corticospinal tracts is a linear abnormal signal that connects the original lesion along the corticospinal tracts, but the conventional MRI signal does not reveal Wallerian degeneration until 4 weeks after stroke. Diffusion tensor imaging (DTI) detects early Wallerian degeneration of the corticospinal tracts, and dynamically observes the process of pathological changes from early subacute stage to chronic stage. 1his article reviews Wallerian degeneration of the corticospinal tracts on DTI after stroke, especially the effect in early Wallerian degeneration, as well as the values in predicting prognosis and late rehabilitation in patients with stroke.