CAJ | 학술논문

已知巨噬细胞在先天免疫系统中发挥着重要的防御作用.近年来,随着慢性低度炎症性疾病概念的提出及深入研究,有关巨噬细胞活化平衡及其在慢性低度炎症性疾病,如肥胖、2型糖尿病、动脉粥样硬化和非酒精性脂肪性肝病等疾病中的致炎作用也逐渐成为当前研究的热点.本文主要阐述了巨噬细胞在这类疾病发生及发展中的重要作用.
이지거서세포재선천면역계통중발휘착중요적방어작용.근년래,수착만성저도염증성질병개념적제출급심입연구,유관거서세포활화평형급기재만성저도염증성질병,여비반、2형당뇨병、동맥죽양경화화비주정성지방성간병등질병중적치염작용야축점성위당전연구적열점.본문주요천술료거서세포재저류질병발생급발전중적중요작용.
It is well known that the macrophages play an important defensive role in the innate immune system. During recent years, with the introduction of the concept of chronic low-grade inflammatory diseases and their further intensive study, the activation and balance of macrophage, as well as its inflammatory effects in chronic lowgrade inflammatory diseases, such as obesity, type 2 diabetes, atherosclerosis, and non-alcoholic fatty liver, are gradually becoming a hot topic of current research. The present article mainly gives an overview of the important role played by macrophages in the inflammatory effects in these diseases.