中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2008年
8期
722-725
,共4页
CHEN Xiao-ping%武娟%PENG Qing%黄鹤%毛振兴%黄彦%JIANG Ling-yun%祝烨%郑庭林%ZHOU Xiao-mei%李宏萍%黄德嘉
CHEN Xiao-ping%武娟%PENG Qing%黃鶴%毛振興%黃彥%JIANG Ling-yun%祝燁%鄭庭林%ZHOU Xiao-mei%李宏萍%黃德嘉
CHEN Xiao-ping%무연%PENG Qing%황학%모진흥%황언%JIANG Ling-yun%축엽%정정림%ZHOU Xiao-mei%리굉평%황덕가
高血压%认知障碍%白蛋白尿
高血壓%認知障礙%白蛋白尿
고혈압%인지장애%백단백뇨
Hypertension%Cognition disorders%Albuminuria
目的 探讨原发性高血压(EH)患者认知功能损害与微量白蛋白尿的关系.方法 采集200例体检高血压病患者的一般资料,测量血压、身高、体重,测定空腹血糖,空腹胰岛素,总胆固醇,甘油三酯,餐后2 h血糖,餐后2 h胰岛素及尿蛋白,对尿蛋白阴性的患者再测定尿微量白蛋白和尿肌酐,最后评价患者的危险分层.根据国际通用的简易智力状况量表(mini mental stateexamination,MMSE)得分进行认知功能评定,按国际标准24分为分界值,将患者分为2组:24分为认知功能正常组,≤24分为认知功能障碍组.结果 200例EH患者,尿蛋白阳性25例,尿蛋白阴性175例.卡方检验结果 提示,尿蛋白阳性与尿蛋白阴性患者之间认知功能差异无统计学意义(P0.05);175例患者测定尿微量白蛋白,进行单因素分析,结果 显示:年龄、文化程度、职业、吸烟史、冠心病史、脑血管病史、危险分层、尿微量白蛋白与尿肌酐比值、餐后2 h胰岛素、胆固醇及舒张压11个因素在认知功能正常组和认知功能障碍组之间的差异有统计学意义(P<0.05);对175例患者进行logistic多因素回归分析显示,与认知功能下降有关的指标是:文化程度、危险分层及尿微量白蛋白.结论 本研究的EH人群文化程度、危险分层和尿微量白蛋白与认知功能降低密切相关,而微量白蛋白尿独立于其他危险因素与认知功能障碍的发生有关,提示微量白蛋白尿可能是认知功能障碍的独立危险因素.
目的 探討原髮性高血壓(EH)患者認知功能損害與微量白蛋白尿的關繫.方法 採集200例體檢高血壓病患者的一般資料,測量血壓、身高、體重,測定空腹血糖,空腹胰島素,總膽固醇,甘油三酯,餐後2 h血糖,餐後2 h胰島素及尿蛋白,對尿蛋白陰性的患者再測定尿微量白蛋白和尿肌酐,最後評價患者的危險分層.根據國際通用的簡易智力狀況量錶(mini mental stateexamination,MMSE)得分進行認知功能評定,按國際標準24分為分界值,將患者分為2組:24分為認知功能正常組,≤24分為認知功能障礙組.結果 200例EH患者,尿蛋白暘性25例,尿蛋白陰性175例.卡方檢驗結果 提示,尿蛋白暘性與尿蛋白陰性患者之間認知功能差異無統計學意義(P0.05);175例患者測定尿微量白蛋白,進行單因素分析,結果 顯示:年齡、文化程度、職業、吸煙史、冠心病史、腦血管病史、危險分層、尿微量白蛋白與尿肌酐比值、餐後2 h胰島素、膽固醇及舒張壓11箇因素在認知功能正常組和認知功能障礙組之間的差異有統計學意義(P<0.05);對175例患者進行logistic多因素迴歸分析顯示,與認知功能下降有關的指標是:文化程度、危險分層及尿微量白蛋白.結論 本研究的EH人群文化程度、危險分層和尿微量白蛋白與認知功能降低密切相關,而微量白蛋白尿獨立于其他危險因素與認知功能障礙的髮生有關,提示微量白蛋白尿可能是認知功能障礙的獨立危險因素.
목적 탐토원발성고혈압(EH)환자인지공능손해여미량백단백뇨적관계.방법 채집200례체검고혈압병환자적일반자료,측량혈압、신고、체중,측정공복혈당,공복이도소,총담고순,감유삼지,찬후2 h혈당,찬후2 h이도소급뇨단백,대뇨단백음성적환자재측정뇨미량백단백화뇨기항,최후평개환자적위험분층.근거국제통용적간역지력상황량표(mini mental stateexamination,MMSE)득분진행인지공능평정,안국제표준24분위분계치,장환자분위2조:24분위인지공능정상조,≤24분위인지공능장애조.결과 200례EH환자,뇨단백양성25례,뇨단백음성175례.잡방검험결과 제시,뇨단백양성여뇨단백음성환자지간인지공능차이무통계학의의(P0.05);175례환자측정뇨미량백단백,진행단인소분석,결과 현시:년령、문화정도、직업、흡연사、관심병사、뇌혈관병사、위험분층、뇨미량백단백여뇨기항비치、찬후2 h이도소、담고순급서장압11개인소재인지공능정상조화인지공능장애조지간적차이유통계학의의(P<0.05);대175례환자진행logistic다인소회귀분석현시,여인지공능하강유관적지표시:문화정도、위험분층급뇨미량백단백.결론 본연구적EH인군문화정도、위험분층화뇨미량백단백여인지공능강저밀절상관,이미량백단백뇨독립우기타위험인소여인지공능장애적발생유관,제시미량백단백뇨가능시인지공능장애적독립위험인소.
Objective To study the relationship between microalbuminuria and cognitive impairment in primary hypertensive patients. Methods A total of 200 hypertensive patients were included in this study. Blood pressure, body height and weight, total cholesterol, triglyceride, fasting plasma glucose, 2 hour-postprandial blood sugar, insulin level and urine protein were measured. Microalbuminuria and urine creatinine were determined in patients without proteinuria. The risk stratification of hypertension was evaluated. The cognitive function and calculate scores were tested by the Mini Mental State Examination (MMSE) and patients were divided into two groups: 24-scores were classified as normal cognition group, ≤24-scores as impaired cognition group. Results Among the 200 hypertensive patients, proteinuria was detected in 25 patients. There was no significant difference in the cognitive function between patients with and without proteinuria (P 0. 05). There were significant differences on age, educational level, occupation, smoking, history of coronary heart disease, history of cerebrovascular disease, the risk stratification of hypertension, microalbuminuria/creatinine ratio, postprandial insulin level, cholesterol and diastolic blood pressure between normal cognition function group and impaired cognition function group (all P <0. 05). Multivariate logistic regression analysis showed that microalbuminuria,educational level and the risk stratification of hypertension were significantly correlated to cognition impairment ( all P < 0. 05 ). Conclusions Educational level, the risk stratification of hypertension and microalbuminuria are associated with cognitive impairment in this patient cohort.
