CAJ | 학술논문

目的探讨粪便隐血试验结合大肠镜检查作为大肠癌普查方式的可行性.方法 2006年9月至2007年5月,对上海市松江区无症状且结直肠癌普通危险度的≥50岁人群以及40-49岁志愿参加普查者行免疫组化法粪便隐血试验,连续3次排便中任意2次粪便标本送检,对任何1次粪便隐血阳性(包括弱阳性)的患者行全结肠镜检查.对息肉的数量、分布位置及病理结果进行统计.结果 ≥50岁受检者共2692例,粪便隐血试验阳性者184例,阳性率6.8%,共56例患者发现了64枚结肠息肉,包括腺瘤件息肉34枚、炎性息肉15枚、增生性息肉15枚,发现直肠癌1例.40～49岁志愿普查者共582例,隐血试验呈阳性者28例,阳性率4.8%,共6例患者发现了6枚息肉,包括腺瘤性息肉1枚、炎性息肉5枚,并发现肠癌2例.多数息肉分布于左半结肠.结论对无症状的结直肠癌普通危险度人群的普查能较早发现结肠息肉,对粪便隐血试验阳性的患者行全结肠镜检查可能较适合社区及广大农村地区结直肠癌的大规模普查.
목적 탐토분편은혈시험결합대장경검사작위대장암보사방식적가행성.방법 2006년9월지2007년5월,대상해시송강구무증상차결직장암보통위험도적≥50세인군이급40-49세지원삼가보사자행면역조화법분편은혈시험,련속3차배편중임의2차분편표본송검,대임하1차분편은혈양성(포괄약양성)적환자행전결장경검사.대식육적수량、분포위치급병리결과진행통계.결과 ≥50세수검자공2692례,분편은혈시험양성자184례,양성솔6.8%,공56례환자발현료64매결장식육,포괄선류건식육34매、염성식육15매、증생성식육15매,발현직장암1례.40～49세지원보사자공582례,은혈시험정양성자28례,양성솔4.8%,공6례환자발현료6매식육,포괄선류성식육1매、염성식육5매,병발현장암2례.다수식육분포우좌반결장.결론 대무증상적결직장암보통위험도인군적보사능교조발현결장식육,대분편은혈시험양성적환자행전결장경검사가능교괄합사구급엄대농촌지구결직장암적대규모보사.
Objective To evaluate the feasibility of fecal occult blood test(FOBT).combined with colonoseopy,in screening of colorectal cancer.Methods From September 2006 to May 2007.healthv volunteers without any colorectal cancer(CRC)related symptoms in Songjiang District of Shanghai,aging from 40 to 49 or older than 50 years,were recruited.The subjects were firstly screened by FOBT with immunohistochemieal method in two of three consecutive stool samples,and colonoscopy was performed in those with positive FOBT in any of the stool samples.The number.type and distribution of detected polyps were recorded.Results Of 2692 subjects over 50 years old,FOBT was positive in 184(6.8%).in which 1 rectal cancer and 64 polyps,including 34 adenomatous polyps,15 inflammatory polyps and 15 hyperplastic polyps.Of 582 subjects aging from 40 to 49 years,FOBT was positive in 28(4.8%),in which 2 adenocarcinoma and 6 polyps,including 1 adenomatous polyp.Most polyps,including adenomatous polyp and high-risk polyp,were mainly found on the left side of colon.Conclusion CRC screening with FOBT and colonoscopy in asymptomatic average-risk people could detect colon polyps at an early stage.Colonoscopy in patients with positive FOBT would be suitable in large scale CRC screening in communities and rural areas.