CAJ | 학술논문

目的:观察3种不同粒径马钱子粉对大鼠佐剂性关节炎的影响.方法:将70R大鼠按体重随机分为7组,即马钱子1、2、3号粉体组,马钱子2号粉体1/2剂量组,马钱子3号粉体1/2剂量组,马钱子3号粉体1/3剂量组和模型对照组,造模后给药21 d后取血清测NO、肿瘤坏死因子(TNF-α),同时每隔7d称重1次.结果:2,3号马钱子粉的药效明显优于1号马钱子粉,且3号马钱子粉与1号马钱子粉的等效剂量约为1/3.结论:通过超微处理能够明显提高马钱子粉的药效.
목적:관찰3충불동립경마전자분대대서좌제성관절염적영향.방법:장70R대서안체중수궤분위7조,즉마전자1、2、3호분체조,마전자2호분체1/2제량조,마전자3호분체1/2제량조,마전자3호분체1/3제량조화모형대조조,조모후급약21 d후취혈청측NO、종류배사인자(TNF-α),동시매격7d칭중1차.결과:2,3호마전자분적약효명현우우1호마전자분,차3호마전자분여1호마전자분적등효제량약위1/3.결론:통과초미처리능구명현제고마전자분적약효.
Objective: To observe the influences of three kinds of grain size of nux vomica powder on the rats with adju-vant-induced arthritis. Methods: Seventy rats were divided into 7 groups according to their body weight: nux vomits power NO.l, NO.2, NO.3 group, nux vomica power NO.2 half dosage group, nux vomiea power NO.3 half dosage group, nux vomica power NO.3 1/3 dosage group and model control group, model established and administration for 21 days, the rats were exam-ined serum NO, TNF-α, and weighing once every 7 days.Results: The effects of NO.2, NO.3 power were better than NO.1 power, the quivalent dose of NO.3 power was about 1/3 same as NO.1 power. Conclusion: It can improve drug action obvi-ously by ultramicro process to nux vomica powder.