CAJ | 학술논문

有机小分子催化的不对称合成反应是目前研究最为活跃的领域之一.不对称Strecker反应是合成光学活性α-氨基酸衍生物的有效手段.目前报道的催化不对称Strecker反应的有机催化剂主要有手性胍类、手性(硫)脲衍生物、氮-氧偶极化合物、手性Bronsted酸等,取得了良好的催化活性和对映选择性.对各类有机小分子催化剂在有机催化不对称Strecker反应中的应用研究进展,以及催化剂结构与反应条件对催化活性和不对称诱导作用的影响进行了简要评述.
유궤소분자최화적불대칭합성반응시목전연구최위활약적영역지일.불대칭Strecker반응시합성광학활성α-안기산연생물적유효수단.목전보도적최화불대칭Strecker반응적유궤최화제주요유수성고류、수성(류)뇨연생물、담-양우겁화합물、수성Bronsted산등,취득료량호적최화활성화대영선택성.대각류유궤소분자최화제재유궤최화불대칭Strecker반응중적응용연구진전,이급최화제결구여반응조건대최화활성화불대칭유도작용적영향진행료간요평술.
Organocatalytic asymmetric reaction is an increasingly active area in oraganic sythesis. Asymmetric Strecker reaction is a powerful tool for the synthesis of α-amino acids. The reported organocatalysts for asymmetric Strecker reaction include chiral guanidines, chiral (thio)urea derivatives, N-oxide compounds, chiral Brφnsted acids and so on, which can catalyze the asymmetric Strecker reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts to asymmetric Strecker reactions are reviewed in this paper. The catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction condition are also discussed.