CAJ | 학술논문

目的为探讨预防性关节内注射丹参注射液对关节粘连的影响.方法将24只日本雄性大耳白兔随机分为3组,每组8只,分别为盐水对照组(A组)、玻璃酸钠对照组(B组)、丹参治疗组(C组).手术切开右后膝关节,搔刮髌上囊前壁,切除大部分髌上囊后壁滑膜和髌下脂肪垫,术毕用长腿管形石膏固定右后肢膝关节于伸直位.每只动物采用的药物品种及剂量分别是:A组注生理盐水0.3 ml、B组注玻璃酸钠0.3 ml、C组注丹参注射液0.3 ml,共4次.4周后空气栓塞处死动物,行关节活动度测量、关节腔行大体观察、髌上囊滑膜组织的组织学观察和总胶原含量检测.结果关节活动度B、C组大于A组(P<0.01),B、C组之间差异无显著性(P>0.05);关节粘连计分B、C组均于小A组(P<0.01),B、C组之间差异无显著性(P>0.05);髌上囊前壁滑膜病变组织学计分B、C组均小于A组(P<0.01),B、C组之间差异无显著性(P>0.05);髌上囊前壁滑膜组织总胶原含量B、C组小于A组(P<0.01),C组小于B组(P<0.01).结论丹参注射液关节内注射能有效预防关节粘连,且与玻璃酸钠的效果类似.
목적 위탐토예방성관절내주사단삼주사액대관절점련적영향.방법 장24지일본웅성대이백토수궤분위3조,매조8지,분별위염수대조조(A조)、파리산납대조조(B조)、단삼치료조(C조).수술절개우후슬관절,소괄빈상낭전벽,절제대부분빈상낭후벽활막화빈하지방점,술필용장퇴관형석고고정우후지슬관절우신직위.매지동물채용적약물품충급제량분별시:A조주생리염수0.3 ml、B조주파리산납0.3 ml、C조주단삼주사액0.3 ml,공4차.4주후공기전새처사동물,행관절활동도측량、관절강행대체관찰、빈상낭활막조직적조직학관찰화총효원함량검측.결과 관절활동도B、C조대우A조(P<0.01),B、C조지간차이무현저성(P>0.05);관절점련계분B、C조균우소A조(P<0.01),B、C조지간차이무현저성(P>0.05);빈상낭전벽활막병변조직학계분B、C조균소우A조(P<0.01),B、C조지간차이무현저성(P>0.05);빈상낭전벽활막조직총효원함량B、C조소우A조(P<0.01),C조소우B조(P<0.01).결론 단삼주사액관절내주사능유효예방관절점련,차여파리산납적효과유사.
Objective To investigate the prophylactic effects of repeated intraarticular injection of Salvia miltiorrhiza on joint adhesion.Methods 24 Japanese rabbits were divided randomly into 3 groups.All right hind knees were made like this:the anterior wall of suprapatellar bursae was scraped,the posterior wall of suprapatellar bursae and the infrapatellar fat pad were cut off.Each knee was injected with physiological saline 0.3 ml for group A,sodium hyaluronate injection 0.3 ml for group B,and Salvia miltiorrhiza injection 0.3 ml for group C.All right hind knees were immobilized in the extension position with a long leg plaster cast for 4 weeks,and injected weekly.Results After 4 weeks,the joint movement range in group B or C was larger than that in group A (P<0.01),and between group B and group C there had no significant difference (P>0.05).The scoring of joint adhesions in group B or C was smaller than that in group A (P<0.01),between group B and group C there had no significant difference(P>0.05).The scoring of histological change of the synovial membrane in group B or C was smaller than that in group A (P<0.01),and there had no significant difference between group Band group C(P>0.05).Total collagens content of the synovial membrane in group B or C was less than that in group A (P<0.01),while that of group C was less than of group B(P<0.01).Conclusion Similar to sodium hyaluronate,salvia miltiorrhiza can effectively prevent joint adhesions.