CAJ | 학술논문

自身免疫性疾病是危害人类健康的重要疾病.随着基因转移技术的发展,基因治疗在自身免疫性疾病中的研究取得了一定进展.通过选择合适的载体转导免疫调节分子、缺陷基因、激活因子、细胞凋亡受体以及诱导免疫耐受等方式来达到治疗目的 .与传统的治疗方法相比,基因治疗具有高效性、靶向性、副作用小等优点.近几年来自身免疫性疾病的基因治疗在临床前实验和临床实验阶段取得了很多成果.
자신면역성질병시위해인류건강적중요질병.수착기인전이기술적발전,기인치료재자신면역성질병중적연구취득료일정진전.통과선택합괄적재체전도면역조절분자、결함기인、격활인자、세포조망수체이급유도면역내수등방식래체도치료목적 .여전통적치료방법상비,기인치료구유고효성、파향성、부작용소등우점.근궤년래자신면역성질병적기인치료재림상전실험화림상실험계단취득료흔다성과.
Autoimmune diseases are a severe human disorders. With the development of gene transfer technology, the study of gene therapy in autoimmune diseases has made some progress. By selecting the appropriate vector to transduce the immune regulatory molecules, defective gene, activating factor, apoptosis receptor into the body and induce the immune tolerance, etc. to achieve therapeutic purposes. Compared with the tradi tional treatment, gene therapy is more effective and targeted with little side effect. In this paper, the achievements of gene therapy for autoimmune diseases in pre-clinical and clinical trials in recent years were reviewed.