CAJ | 학술논문

目的探讨美托洛尔对原发性高血压患者颈动脉粥样硬化的影响.方法将70例原发性高血压患者随机分为对照组(35例,常规治疗)和治疗组(35例,常规治疗+美托洛尔25～50 mg/d),连续治疗12周.在治疗前后测定两组患者的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(KDL-C)、高密度脂蛋白胆固醇(HDL-C)及C反应蛋白(CRP);行颈动脉多普勒超声检查,记录颈动脉内膜-中层厚度(IMT),计算颈动脉斑块积分和斑块检出率.结果治疗12周后,治疗组的CRP、IMT、颈动脉斑块积分数值及斑块检出率显著降低(P值<0.05);治疗组的CRP、IMT、颈动脉斑块积分数值及斑块检出率的降幅显著大于对照组(P值<0.05).结论美托洛尔可以延缓颈动脉粥样硬化的发展并消退颈动脉粥样斑块.
목적 탐토미탁락이대원발성고혈압환자경동맥죽양경화적영향.방법 장70례원발성고혈압환자수궤분위대조조(35례,상규치료)화치료조(35례,상규치료+미탁락이25～50 mg/d),련속치료12주.재치료전후측정량조환자적혈청총담고순(TC)、감유삼지(TG)、저밀도지단백담고순(KDL-C)、고밀도지단백담고순(HDL-C)급C반응단백(CRP);행경동맥다보륵초성검사,기록경동맥내막-중층후도(IMT),계산경동맥반괴적분화반괴검출솔.결과 치료12주후,치료조적CRP、IMT、경동맥반괴적분수치급반괴검출솔현저강저(P치<0.05);치료조적CRP、IMT、경동맥반괴적분수치급반괴검출솔적강폭현저대우대조조(P치<0.05).결론 미탁락이가이연완경동맥죽양경화적발전병소퇴경동맥죽양반괴.
Objective To explore the effect of metoprolol on carotid atherosclerosis.Methods Seventy patients of essential hypertensive were randomly divided into control group ( n=35 ) and treatment group ( n=35, metoprolol 25 ～ 50 mg/d ), for twelve weeks continuously.Serum levels of total cholesterol ( TC ) triglycerides ( TG ), low-density lipoprotein holesterol ( LDL-C ), high-density lipo-protein cholesterol ( HDL-C ) and C-reactive protein were determined for both groups before and after treatment.Carotid intima-medial thickness (IMT ) was measured by ultrasound.The incidence of carotid plaque and carotid plaque scores were calculated.Results After the treatment of 12 weeks, CRP, IMT, the incidence of carotid plaque and carotid plaque scores were all significantly reduced ( P< 0.05 ).The reduction of CRP, IMT, incidence of carotid plaque and carotid plaque scores were significantly bigger in treatment group than those in control group ( P< 0.05 ).Conclusions Metoprolol can retard the progressive development of carotid atherosclerosis and the carotid artery plaque can be regressed.