国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
8期
673-675
,共3页
脑卒中后抑郁%血清脑源性神经营养因子%柴胡加龙骨牡蛎汤
腦卒中後抑鬱%血清腦源性神經營養因子%柴鬍加龍骨牡蠣湯
뇌졸중후억욱%혈청뇌원성신경영양인자%시호가용골모려탕
Post-stroke depression%Brain-derived neurotrophic factor%Chaihujia-Longgumuli decoction
目的 探讨柴胡加龙骨牡蛎汤对脑卒中后抑郁(post-stroke depression,PSD)患者血清脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)水平及神经功能的影响.方法 将76例PSD患者按随机数字表法分为两组各38例,对照组采用常规疗法治疗,研究组在对照组治疗基础上加用柴胡加龙骨牡蛎汤治疗.治疗结束后比较2组患者血清BDNF水平,汉密顿抑郁量表(HAMD-24)、神经功能缺损程度评分量表(MESSS)、脑卒中康复运动功能评定表(STREAM)评分情况及临床疗效.结果 治疗3周、6周后研究组血清BDNF水平显著高于对照组(t值分别为2.52、2.14,P均＜0.05);HAMD 评分(t值分别为2.07、3.02)、MESSS评分(t值分别为2.51、4.50)与对照组比较,差异均有统计学意义(P均＜O.05):治疗6周后两组STREAM评分比较,差异有统计学意义(t=2.01,P＜0.05);两组临床疗效比较,差异有统计学意义(x2=7.93,P＜0.05).结论 柴胡加龙骨牡蛎汤可提高PSD患者血清BDNF水平,缓解抑郁症状,改善神经、运动功能.
目的 探討柴鬍加龍骨牡蠣湯對腦卒中後抑鬱(post-stroke depression,PSD)患者血清腦源性神經營養因子(brain-derived neurotrophic factor,BDNF)水平及神經功能的影響.方法 將76例PSD患者按隨機數字錶法分為兩組各38例,對照組採用常規療法治療,研究組在對照組治療基礎上加用柴鬍加龍骨牡蠣湯治療.治療結束後比較2組患者血清BDNF水平,漢密頓抑鬱量錶(HAMD-24)、神經功能缺損程度評分量錶(MESSS)、腦卒中康複運動功能評定錶(STREAM)評分情況及臨床療效.結果 治療3週、6週後研究組血清BDNF水平顯著高于對照組(t值分彆為2.52、2.14,P均＜0.05);HAMD 評分(t值分彆為2.07、3.02)、MESSS評分(t值分彆為2.51、4.50)與對照組比較,差異均有統計學意義(P均＜O.05):治療6週後兩組STREAM評分比較,差異有統計學意義(t=2.01,P＜0.05);兩組臨床療效比較,差異有統計學意義(x2=7.93,P＜0.05).結論 柴鬍加龍骨牡蠣湯可提高PSD患者血清BDNF水平,緩解抑鬱癥狀,改善神經、運動功能.
목적 탐토시호가용골모려탕대뇌졸중후억욱(post-stroke depression,PSD)환자혈청뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)수평급신경공능적영향.방법 장76례PSD환자안수궤수자표법분위량조각38례,대조조채용상규요법치료,연구조재대조조치료기출상가용시호가용골모려탕치료.치료결속후비교2조환자혈청BDNF수평,한밀돈억욱량표(HAMD-24)、신경공능결손정도평분량표(MESSS)、뇌졸중강복운동공능평정표(STREAM)평분정황급림상료효.결과 치료3주、6주후연구조혈청BDNF수평현저고우대조조(t치분별위2.52、2.14,P균＜0.05);HAMD 평분(t치분별위2.07、3.02)、MESSS평분(t치분별위2.51、4.50)여대조조비교,차이균유통계학의의(P균＜O.05):치료6주후량조STREAM평분비교,차이유통계학의의(t=2.01,P＜0.05);량조림상료효비교,차이유통계학의의(x2=7.93,P＜0.05).결론 시호가용골모려탕가제고PSD환자혈청BDNF수평,완해억욱증상,개선신경、운동공능.
Objective To investigate the effects of Chaihujia-Longgumuli decoction on brain-derived neurotrophic factor (BDNF) levels and neurological function in patients with post-stroke depression (PSD). Methods Patients meet the diagnostic criteria of the PSD were randomly recurited into a control group and a study group.The control group received conventional therapy. On this basis, the study group was treated with Chaihujia-Longgumuli decoction.The levels of serum BDNF,Hamilton Depression Scale(HAMD-24), neurological impairment rating scale (MESSS), stroke rehabilitation assessment of movement table (STREAM) rate situation and clinical efficacy were compared between the two groups. Results After treated for 3 weeks and 6 weeks,the serum BDNF level in the study group was significantly higher(t=2.52、 2.14. P＜0.05) than the control group, while HAMD score was significantly lower than the control group(t=2.07、3.02,P＜0.01). MESSS score in the study group was also significantly lower than control group (t=2.51、4.50, P＜0.01). After 6 weeks treatment both STREAM score(t=2.01, P＜0.05) and the therapeutic effects (x2=7.93,P＜0.05) showed significant difference between the two groups. Conclusion Chaihujia-Longgumuli decoction can increase serum BDNF levels, reduce depression, improve nerve and motor function and boost clinical efficacy.
