CAJ | 학술논문

目的:探讨中药络泰和黄芪注射液与西药结合治疗冠心病的效果和作用机制,分析比较两种药物对冠心病患者血管内皮细胞功能的影响. 方法:用 RIA和 ELISA法检测冠心病患者治疗前后血浆中内皮素-1和血管性假血友病因子 (vWF)水平的变化,并与只用西药治疗患者进行比较. 结果:络泰组和黄芪组冠心病患者治疗前血浆中内皮素-1含量为( 77.56± 15.84)和( 76.74± 15.30) ng/L, vWF为 (97.22± 33.84)%和 (90.30± 17.49)%,水平均明显高于对照组( P< 0.01);络泰组和黄芪组在治疗后内皮素-1为( 57.90± 11.57)和 (57.83± 8.56) ng/L, vWF含量 (59.73± 14.8)%和 (60.42± 17.11)%,两组与治疗前相比明显降低( P< 0.01);单用西药组治疗后内皮素-1水平降低的不明显( P >0.05), vWF与治疗前相比差异有显著性意义( P< 0.05) ,与络泰组和黄芪组比差异有显著性意义( P< 0.01). 结论:在常规治疗冠心病西药的基础上,再加以中药络泰和黄芪注射液,可以提高对冠心病的治疗效果,改善血管内皮功能.
목적:탐토중약락태화황기주사액여서약결합치료관심병적효과화작용궤제,분석비교량충약물대관심병환자혈관내피세포공능적영향. 방법:용 RIA화 ELISA법검측관심병환자치료전후혈장중내피소-1화혈관성가혈우병인자 (vWF)수평적변화,병여지용서약치료환자진행비교. 결과:락태조화황기조관심병환자치료전혈장중내피소-1함량위( 77.56± 15.84)화( 76.74± 15.30) ng/L, vWF위 (97.22± 33.84)%화 (90.30± 17.49)%,수평균명현고우대조조( P< 0.01);락태조화황기조재치료후내피소-1위( 57.90± 11.57)화 (57.83± 8.56) ng/L, vWF함량 (59.73± 14.8)%화 (60.42± 17.11)%,량조여치료전상비명현강저( P< 0.01);단용서약조치료후내피소-1수평강저적불명현( P >0.05), vWF여치료전상비차이유현저성의의( P< 0.05) ,여락태조화황기조비차이유현저성의의( P< 0.01). 결론:재상규치료관심병서약적기출상,재가이중약락태화황기주사액,가이제고대관심병적치료효과,개선혈관내피공능.
AIM:To discuss the effects and mechanism of the combined therapy of Traditional Chinese Medicine(TCM) luotai and huangqi(Astragalus root) injection and western medicine in the treatment of coronary heart disease. To analysis and compare the functional index of vascular endothelium of these two TCM in coronary heart disease patients. METHODS:The serous level changes of endothelin-1(ET-1) and von Willebrand factor(vWF) before and after therapy in coronary heart disease patients were analyzed by RIA and ELISA,and compared with those who only received western medicine therapy. RESULTS:ET-1 content of luotai and huangqi group before therapy was (77.56± 15.84) and (76.74± 15.30) ng/L respectively;and vMF was (97.22± 33.84)% and (90.30± 17.49)% respectively, which were all higher than that of the control group(P< 0.01).ET-1 content of luotai and huangqi group after therapy was (57.90± 11.57) and (57.83± 8.56) ng/L respectively; and vMF was (59.73± 14.8)% and (60.42± 17.11)% respectively,which were both significantly decreased compared with the value before therapy(P< 01.01).ET-1 content was no significant decrease after therapy in western medicine therapy group(P >0.05),while the changes of vMF had significant difference(P< 0.05).There were significant differences between western medicine therapy group and TCM groups(P< 0.01). CONCLUSION:On the basis of routine western medicine therapy in the treatment of coronary heart disease,the therapeutic effectiveness can be increased and the function of vascular endothelium can be improved by combining the treatment with TCM luotai and huangqi injection.