检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2010年
1期
17-20
,共4页
阮水良%刘德许%王波%毕军%季霞%吴君%杜瑛媛
阮水良%劉德許%王波%畢軍%季霞%吳君%杜瑛媛
원수량%류덕허%왕파%필군%계하%오군%두영원
胰岛素样生长因子-1%日本血吸虫病%肝功能%肝纤维化
胰島素樣生長因子-1%日本血吸蟲病%肝功能%肝纖維化
이도소양생장인자-1%일본혈흡충병%간공능%간섬유화
Insulin-like growth factor-1%Schistosomiasis japonica%Liver function%Liver fibrosis
目的 研究血吸虫性肝纤维化患者血清胰岛素样生长因子-1(IGF-1)与肝功能之间的关系.方法 收集50例诊断明确的血吸虫性肝纤维化患者临床资料,以30名体检的健康人作为对照,分别测定血清IGF-1、肝功能、肝纤维化等指标.结果 血吸虫性肝纤维化组的IGF-1高于健康对照组(P<0.05).血吸虫性肝纤维化组的IGF-1浓度在不同肝功能Child-pugh分级中差异有统计学意义,Child-pugh分级越差,IGF-1浓度越高.在所有80例被检者中IGF-1与总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)、天门冬氨酸氨基转移酶(AST)呈正相关(r=0.554、0.570、0.479、0.016,P<0.05),与血清总蛋白(TP)、白蛋白(Alb)呈负相关(r=-0.257、-0.531, P<0.05).IGF-1与透明质酸(HA)、Ⅳ型胶原(C-Ⅳ)、Ⅲ型胶原(C-Ⅲ)呈正相关(r=0.580、0.655、0.542, P<0.05).结论 血吸虫性肝纤维化患者血清IGF-1增加与肝功能减退、肝纤维化程度相一致,可能与血吸虫性肝纤维化的发生、发展有关.
目的 研究血吸蟲性肝纖維化患者血清胰島素樣生長因子-1(IGF-1)與肝功能之間的關繫.方法 收集50例診斷明確的血吸蟲性肝纖維化患者臨床資料,以30名體檢的健康人作為對照,分彆測定血清IGF-1、肝功能、肝纖維化等指標.結果 血吸蟲性肝纖維化組的IGF-1高于健康對照組(P<0.05).血吸蟲性肝纖維化組的IGF-1濃度在不同肝功能Child-pugh分級中差異有統計學意義,Child-pugh分級越差,IGF-1濃度越高.在所有80例被檢者中IGF-1與總膽紅素(TBil)、直接膽紅素(DBil)、間接膽紅素(IBil)、天門鼕氨痠氨基轉移酶(AST)呈正相關(r=0.554、0.570、0.479、0.016,P<0.05),與血清總蛋白(TP)、白蛋白(Alb)呈負相關(r=-0.257、-0.531, P<0.05).IGF-1與透明質痠(HA)、Ⅳ型膠原(C-Ⅳ)、Ⅲ型膠原(C-Ⅲ)呈正相關(r=0.580、0.655、0.542, P<0.05).結論 血吸蟲性肝纖維化患者血清IGF-1增加與肝功能減退、肝纖維化程度相一緻,可能與血吸蟲性肝纖維化的髮生、髮展有關.
목적 연구혈흡충성간섬유화환자혈청이도소양생장인자-1(IGF-1)여간공능지간적관계.방법 수집50례진단명학적혈흡충성간섬유화환자림상자료,이30명체검적건강인작위대조,분별측정혈청IGF-1、간공능、간섬유화등지표.결과 혈흡충성간섬유화조적IGF-1고우건강대조조(P<0.05).혈흡충성간섬유화조적IGF-1농도재불동간공능Child-pugh분급중차이유통계학의의,Child-pugh분급월차,IGF-1농도월고.재소유80례피검자중IGF-1여총담홍소(TBil)、직접담홍소(DBil)、간접담홍소(IBil)、천문동안산안기전이매(AST)정정상관(r=0.554、0.570、0.479、0.016,P<0.05),여혈청총단백(TP)、백단백(Alb)정부상관(r=-0.257、-0.531, P<0.05).IGF-1여투명질산(HA)、Ⅳ형효원(C-Ⅳ)、Ⅲ형효원(C-Ⅲ)정정상관(r=0.580、0.655、0.542, P<0.05).결론 혈흡충성간섬유화환자혈청IGF-1증가여간공능감퇴、간섬유화정도상일치,가능여혈흡충성간섬유화적발생、발전유관.
Objective To study the relationship between serum insulin-like growth factor-1 (IGF-1) and liver function in patients with schistosomal liver fibrosis. Methods The clinical data of 80 cases (50 cases diagnosed with schistosomiasis and 30 cases from health examination as controls) were collected. The IGF-1 level, liver function and liver fibrosis indexes were detected. Results The IGF-1 level was higher in patients with schistosomiasis than in the controls(P<0.05). The IGF-1 level in patients with schistosomiasis was correlated with liver function Child-pugh classification. The IGF-1 level was positively correlated with the levels of total bilirubin(TBil), direct bilirubin(DBil), indirect bilirubin(IBil) and aspartate aminotransferase (AST) (r=0.554, 0.570, 0.479,0.016, P<0.05), and was negatively correlated with the levels of serum total protein (TP) and albumin (Alb)(r=-0.257, -0.531, P<0.05). The IGF-1 level was also positively correlated with hyaluronic acid (HA), type Ⅳ collagen (C-Ⅳ) and type Ⅲ collagen (C-Ⅲ)(r=0.580, 0.655, 0.542, P<0.05). Conclusions The serum IGF-1 level increases in patients with schistosomiasis, and this level increases with hypohepatia and the progression of liver fibrosis. The IGF-1 might be involved in the pathogenesis of liver fibrosis.
