中国老年学杂志
中國老年學雜誌
중국노년학잡지
CHINESE JOURNAL OF GERONTOLOGY
2009年
24期
3169-3172
,共4页
陈恩静%甘华%王辉%钟清%沈青%谯林
陳恩靜%甘華%王輝%鐘清%瀋青%譙林
진은정%감화%왕휘%종청%침청%초림
氧化型低密度脂蛋白%慢性肾衰竭%冠心病
氧化型低密度脂蛋白%慢性腎衰竭%冠心病
양화형저밀도지단백%만성신쇠갈%관심병
Oxidized low density lipoprotein%Chronic renal failure%Coronary heart disease
目的 探讨慢性肾衰竭(CRF)合并冠心病患者血浆氧化型低密度脂蛋白(ox-LDL)水平变化及临床意义.方法 用ELISA方法测定299例住院病人和111例健康自愿者血浆ox-LDL水平,同时测定血浆TC、TG、HDL-C、LDL-C、Scr与ALB指标.结果 血浆ox-LDL水平:CRF合并冠心病组[n=148,(430.88±190.56) μg/dl]明显高于非合并冠心病组[n=72,(139.13±50.15) μg/dl](P<0.05);CRF合并不稳定性心绞痛组[n=66,(545.58±202.89) μg/dl]明显高于合并稳定性心绞痛组[n=82,(255.75±112.3) μg/dl](P<0.05).CRF组[n=220,(372.18±153.68) μg/dl]明显高于正常对照组[n=111,(34.90±17.65) μg/dl]与慢性肾炎组[n=79,(40.64±20.20) μg/dl](P<0.05);但慢性肾炎组与正常对照组无显著性差异(P>0.05).结论 CRF患者血浆ox-LDL水平显著高于正常人及慢性肾炎患者,并发冠心病的患者其血浆ox-LDL水平升高更为明显,其中合并不稳定性心绞痛患者血浆ox-LDL水平尤其高.因此,CRF患者血浆ox-LDL浓度的高低可间接提示动脉粥样硬化的存在及严重程度.
目的 探討慢性腎衰竭(CRF)閤併冠心病患者血漿氧化型低密度脂蛋白(ox-LDL)水平變化及臨床意義.方法 用ELISA方法測定299例住院病人和111例健康自願者血漿ox-LDL水平,同時測定血漿TC、TG、HDL-C、LDL-C、Scr與ALB指標.結果 血漿ox-LDL水平:CRF閤併冠心病組[n=148,(430.88±190.56) μg/dl]明顯高于非閤併冠心病組[n=72,(139.13±50.15) μg/dl](P<0.05);CRF閤併不穩定性心絞痛組[n=66,(545.58±202.89) μg/dl]明顯高于閤併穩定性心絞痛組[n=82,(255.75±112.3) μg/dl](P<0.05).CRF組[n=220,(372.18±153.68) μg/dl]明顯高于正常對照組[n=111,(34.90±17.65) μg/dl]與慢性腎炎組[n=79,(40.64±20.20) μg/dl](P<0.05);但慢性腎炎組與正常對照組無顯著性差異(P>0.05).結論 CRF患者血漿ox-LDL水平顯著高于正常人及慢性腎炎患者,併髮冠心病的患者其血漿ox-LDL水平升高更為明顯,其中閤併不穩定性心絞痛患者血漿ox-LDL水平尤其高.因此,CRF患者血漿ox-LDL濃度的高低可間接提示動脈粥樣硬化的存在及嚴重程度.
목적 탐토만성신쇠갈(CRF)합병관심병환자혈장양화형저밀도지단백(ox-LDL)수평변화급림상의의.방법 용ELISA방법측정299례주원병인화111례건강자원자혈장ox-LDL수평,동시측정혈장TC、TG、HDL-C、LDL-C、Scr여ALB지표.결과 혈장ox-LDL수평:CRF합병관심병조[n=148,(430.88±190.56) μg/dl]명현고우비합병관심병조[n=72,(139.13±50.15) μg/dl](P<0.05);CRF합병불은정성심교통조[n=66,(545.58±202.89) μg/dl]명현고우합병은정성심교통조[n=82,(255.75±112.3) μg/dl](P<0.05).CRF조[n=220,(372.18±153.68) μg/dl]명현고우정상대조조[n=111,(34.90±17.65) μg/dl]여만성신염조[n=79,(40.64±20.20) μg/dl](P<0.05);단만성신염조여정상대조조무현저성차이(P>0.05).결론 CRF환자혈장ox-LDL수평현저고우정상인급만성신염환자,병발관심병적환자기혈장ox-LDL수평승고경위명현,기중합병불은정성심교통환자혈장ox-LDL수평우기고.인차,CRF환자혈장ox-LDL농도적고저가간접제시동맥죽양경화적존재급엄중정도.
Objective To investigate the plasma levels of oxidized low density lipoprotein (ox-LDL) in patients with chronic renal failure(CRF) and coronary heart disease. Methods 299 patients and 111 healthy subjects were taken venous plasma after fasting for 12 h and vegetable diet for one day. The levels of ox-LDL were measured by sandwich ELISA. Results The plasma levels of ox-LDL were significantly elevated in CRF patients [(372.18±135.68)μg/dl , n=220] compared with those of control subjects [ (34.90±17.65) μg/dl ,n=111] and chronic glomerulonenephritis patients[(40.64±20.20) μg/dl, n=79] (P<0.05) .The levels of ox-LDL of CRF patients with coronary heart disease (CHD) [ n=148, (430.88±190.56) μg/dl] were more than those of CRF patients without CHD[n=72, (139.13±50.15) μg/dl] (P<0.05).And then, the levels of ox-LDL in CRF patients with unstable angina pectoris [n=82, (545.58±202.89)μg/dl] were significantly higher than those of CRF patients with stable angina pectoris [n=66, (255.75±112.38) μg/dl) (P<0.05)]. Conclusions The elevated level of plasma ox-LDL in CRF patients may result in artherosclerosis disease.
