CAJ | 학술논문

目的探讨肿瘤相关抗原CA125在正常生育期妇女宫颈分泌物、阴道分泌物和血清中的表达,探索宫颈、阴道分泌物中肿瘤标志物的初步检测价值.方法 145例病人分3组,组1(20～29岁)、组2(30～39岁)、组3(40岁以上),采用电化学发光免疫分析法测定145例正常生育期妇女的官颈分泌物、阴道分泌物和血清CA125水平.结果正常妇女官颈分泌物、阴道分泌物、血清中的CA125水平在不同年龄组比较均无显著性差异(P>0.05);组1、组2、组3宫颈分泌物、阴道分泌物和血清CA125分别比较,各年龄组宫颈分泌物与阴道分泌物CA125比较有极显著差异(P<0.001),宫颈分泌物与血清CA125比较有极显著差异(P<0.001),阴道分泌物与血清CA125比较有极显著差异(P<0.001);145例宫颈分泌物CA125平均水平(497.82±75.29)U/ml,阴道分泌物CA125(114.66±26.40)U/ml,血清CA125(18.06±3.35)U/ml,宫颈分泌物与阴道分泌物CA125比较有极显著差异(P<0.001),宫颈分泌物与血清CA125比较有极显著差异(P<0.001),阴道分泌物与血清CA125比较有极显著差异(P<0.001).结论 CA125在正常生育期妇女宫颈分泌物、阴道分泌物中有表达,明显高于血清中CA125浓度,可能比血清CA125更为敏感,更便于早期检测.
목적 탐토종류상관항원CA125재정상생육기부녀궁경분비물、음도분비물화혈청중적표체,탐색궁경、음도분비물중종류표지물적초보검측개치.방법 145례병인분3조,조1(20～29세)、조2(30～39세)、조3(40세이상),채용전화학발광면역분석법측정145례정상생육기부녀적관경분비물、음도분비물화혈청CA125수평.결과 정상부녀관경분비물、음도분비물、혈청중적CA125수평재불동년령조비교균무현저성차이(P>0.05);조1、조2、조3궁경분비물、음도분비물화혈청CA125분별비교,각년령조궁경분비물여음도분비물CA125비교유겁현저차이(P<0.001),궁경분비물여혈청CA125비교유겁현저차이(P<0.001),음도분비물여혈청CA125비교유겁현저차이(P<0.001);145례궁경분비물CA125평균수평(497.82±75.29)U/ml,음도분비물CA125(114.66±26.40)U/ml,혈청CA125(18.06±3.35)U/ml,궁경분비물여음도분비물CA125비교유겁현저차이(P<0.001),궁경분비물여혈청CA125비교유겁현저차이(P<0.001),음도분비물여혈청CA125비교유겁현저차이(P<0.001).결론 CA125재정상생육기부녀궁경분비물、음도분비물중유표체,명현고우혈청중CA125농도,가능비혈청CA125경위민감,경편우조기검측.
Objective To investigate the tomor-associated antigen CA!25 expression in the serum and cervical and vaginal secretions in women during normal reproductive period, and explore the clinical value of detecting tumor markers in the cervical and vaginal secretions. Methods A total of 145 women in reproductive period were divided into 3 age groups (20-29 years, 30-39 years, and over 40 years), and their CA125 levels in cervical secretion, vaginal secretion and serum were detected by automatic electro-chemiluminescent immunoassay. Results CA125 levels in the cervical secretion, vaginal secretion and serum showed no significant difference between the 3 age groups (P>0.05). In each group, CA125 levels differed significantly between the cervical secretion, vaginal secretion and serum (P<0.001). In the 145 women, the average CA125 level was 497.82±75.29 U/ml in the cervical secretion, 114.66±26.40 U/ml in vaginal secretion and 18.06±3.35 U/ml in serum, showing significant differences between them (P<0.001). Conclusion CA 125 expression level is significantly higher in the cervical and vaginal secretions than in the serum in women in normal reproductive period, and its levels in cervical and vaginal secretions can be more sensitive and convenient for early detection of related diseases.