CAJ | 학술논문

对中药萹蓄化学成分及归膀胱经的药性进行了初步研究.确定抑菌活性有效部位,并采用植化方法分离鉴定了化学成分;利用高效液相和液-质联用技术,研究入血成分及其在体内脏器中的分布.结果表明,总黄酮是萹蓄抑菌活性的有效部位,主要含有山奈酚(Ⅰ),槲皮素(Ⅱ),杨梅素(Ⅲ),杨梅树皮苷(Ⅳ),胡桃宁(Ⅴ)和萹蓄苷(Ⅵ).大鼠口服萹蓄总黄酮后,在其血浆中可以检测到化合物Ⅴ和Ⅵ.Ⅵ在膀胱经脏腑中有分布,初步验证了萹蓄归膀胱经的药性理论.
대중약편축화학성분급귀방광경적약성진행료초보연구.학정억균활성유효부위,병채용식화방법분리감정료화학성분;이용고효액상화액-질련용기술,연구입혈성분급기재체내장기중적분포.결과표명,총황동시편축억균활성적유효부위,주요함유산내분(Ⅰ),곡피소(Ⅱ),양매소(Ⅲ),양매수피감(Ⅳ),호도저(Ⅴ)화편축감(Ⅵ).대서구복편축총황동후,재기혈장중가이검측도화합물Ⅴ화Ⅵ.Ⅵ재방광경장부중유분포,초보험증료편축귀방광경적약성이론.
The chemical constituents and meridian doctrine of Polygonum aviculare were investigated in the present study. Antibacterial experiment showed that the total flavonoids of P. aviculare (TFP) were the active portion of P. aviculare. Six flavonoids were identified from TFP by the phytochemical method, including kaempferol (Ⅰ), quercetin (Ⅱ), myricetin (Ⅲ), myricitrin (Ⅳ), juglanin (Ⅴ) and avicularin (Ⅵ). Avicularin (Ⅵ) and juglanin (Ⅴ) were detected in the plasma after taking TFP orally, and avicularin (Ⅵ) was present in the bladder meridain tissues after intravenous administration of avicularin and juglanin. The results of this study validated the theory that P. aviculare belongs to the bladder meridian.