CAJ | 학술논문

合成和表征了一种新的N-苯基二吡啶甲基胺(phdpa)铜配合物[(phdpa)Cu(SCN)](ClO4).X-衍射晶体结构数据显示配合物中铜原子与配体phdpa中3个N原子、SCN-中S原子和邻近分子中SCN-中N原子配位,形成扭曲八面体结构.生物活性数据显示该铜配合物抑制HepG-2细胞的生长,半数抑制率为10.4 μmol· L-1.进一步机理研究数据显示这种SCN-桥联的铜配合物能诱导HepG-2细胞核的分裂,降低其耗氧量和ROS的含量,这表明该铜配合物是一种能影响HepG-2细胞氧代谢的多功能配合物.
합성화표정료일충신적N-분기이필정갑기알(phdpa)동배합물[(phdpa)Cu(SCN)](ClO4).X-연사정체결구수거현시배합물중동원자여배체phdpa중3개N원자、SCN-중S원자화린근분자중SCN-중N원자배위,형성뉴곡팔면체결구.생물활성수거현시해동배합물억제HepG-2세포적생장,반수억제솔위10.4 μmol· L-1.진일보궤리연구수거현시저충SCN-교련적동배합물능유도HepG-2세포핵적분렬,강저기모양량화ROS적함량,저표명해동배합물시일충능영향HepG-2세포양대사적다공능배합물.
A new copper (Ⅱ) complex of N-benzyl di (2-pyridylmethyl)amine (phdpa) was synthesized and characterized.X-ray crystal structure shows that the copper atom in [(phdpa)Cu(SCN)](ClO4) is coordinated with a phdpa and a SCN-forming a coordinated polymer.In vitro essay results show that this copper(Ⅱ) complex exhibits good inhibition on the proliferation of HepG-2 cells with IC50 of 10.4 μmol ·L-1.In addition,[(phdpa)Cu(SCN)] (ClO4) can induce the obvious nucleus fragmentation of HepG-2 cells,decrease the O2 consumption and reactive oxygen species (ROS) level in HepG-2 cells,indicating that this SCN-bridged copper(Ⅱ) complex is a multi-functional copper(Ⅱ) complex.CCDC:840495.