中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2009年
5期
406-408
,共3页
申占龙%王杉%叶颖江%姜可伟%杨晓东%孙昆昆%虞有智
申佔龍%王杉%葉穎江%薑可偉%楊曉東%孫昆昆%虞有智
신점룡%왕삼%협영강%강가위%양효동%손곤곤%우유지
胃肿瘤%肿瘤转移%预后%病理学,临床
胃腫瘤%腫瘤轉移%預後%病理學,臨床
위종류%종류전이%예후%병이학,림상
Stomach neoplasm%Neoplasm metastasis%Prognosis%Pathology,clinical
目的 探讨NDRG1蛋白在胃癌组织中表达情况以及与临床病理指标和预后的关系.方法 应用免疫组化法检测110例胃癌及相应癌旁组织中NDRG1蛋白的表达,并分析其与胃癌患者临床病理指标及预后的相关性.结果 本组胃癌组织中NDRG1蛋白表达阳性率为71.8%,癌旁组织中阳性率为100%,并且胃癌组织中NDRG1蛋白多为低表达,而癌旁组织多为高表达.NDRG1蛋白表达与胃癌浸润深度、TNM分期以及有无淋巴转移具有相关性,而与患者年龄、性别、分化程度、大体类型、远处转移无关.NDRG1蛋白低表达胃癌患者预后较差,1、3、5年总生存率和无病生存率分别为84.2%、53.9%、21.1%和60.5%、31.6%、19.7%.结论 NDRG1在胃癌组织中多呈低表达,与肿瘤的浸润、转移密切相关,可能是胃癌发病及肿瘤转移的一个候选抑癌基因,对胃癌发病及转移的早期诊断和预后判断有重要指导意义.
目的 探討NDRG1蛋白在胃癌組織中錶達情況以及與臨床病理指標和預後的關繫.方法 應用免疫組化法檢測110例胃癌及相應癌徬組織中NDRG1蛋白的錶達,併分析其與胃癌患者臨床病理指標及預後的相關性.結果 本組胃癌組織中NDRG1蛋白錶達暘性率為71.8%,癌徬組織中暘性率為100%,併且胃癌組織中NDRG1蛋白多為低錶達,而癌徬組織多為高錶達.NDRG1蛋白錶達與胃癌浸潤深度、TNM分期以及有無淋巴轉移具有相關性,而與患者年齡、性彆、分化程度、大體類型、遠處轉移無關.NDRG1蛋白低錶達胃癌患者預後較差,1、3、5年總生存率和無病生存率分彆為84.2%、53.9%、21.1%和60.5%、31.6%、19.7%.結論 NDRG1在胃癌組織中多呈低錶達,與腫瘤的浸潤、轉移密切相關,可能是胃癌髮病及腫瘤轉移的一箇候選抑癌基因,對胃癌髮病及轉移的早期診斷和預後判斷有重要指導意義.
목적 탐토NDRG1단백재위암조직중표체정황이급여림상병리지표화예후적관계.방법 응용면역조화법검측110례위암급상응암방조직중NDRG1단백적표체,병분석기여위암환자림상병리지표급예후적상관성.결과 본조위암조직중NDRG1단백표체양성솔위71.8%,암방조직중양성솔위100%,병차위암조직중NDRG1단백다위저표체,이암방조직다위고표체.NDRG1단백표체여위암침윤심도、TNM분기이급유무림파전이구유상관성,이여환자년령、성별、분화정도、대체류형、원처전이무관.NDRG1단백저표체위암환자예후교차,1、3、5년총생존솔화무병생존솔분별위84.2%、53.9%、21.1%화60.5%、31.6%、19.7%.결론 NDRG1재위암조직중다정저표체,여종류적침윤、전이밀절상관,가능시위암발병급종류전이적일개후선억암기인,대위암발병급전이적조기진단화예후판단유중요지도의의.
Objective To explore the expression of N-myc downstream regulated gene 1 (NDRG1) in gastric carcinoma and the relationship with clinicopathological parameters and prognosis. Methods The expression of NDRGI was detected by immunohisto chemistry in formalin-fixed and paraffin-embedded sections with a total of 220 specimens including 110 gastric carcinoma and 110 corresponding paraneoplastic tissue. The correlation between clinicopathological parameters and the expression of NDRG1 in gastric carcinoma were also analyzed. Results Low expression of NDRG1 was detected in most gastric carcinoma sections. Among the gastric cancer tissues, NDRG1 protein expression was significantly lower in tumors with more advanced pathological stage, local tumor invasion and lymphatic metastases. There was no significant difference in sex, age, tumor differentiation and gross types of the tumor. The 1-, 3- and 5 year survival and disease free survival in patients with low NDRG1 protein expression was 84.2%, 53.9%, 21.1%, and 60.5%, 31.6%, 19.7%, respectively, which was signifivantly poorer when compared with patients with high NDRG1 protein expression. Conclusion The expression of NDRG1 is low in the majority of patients with gastric carcinoma, which was in a close relationship with advanced stage, local invasion and lymphatic metastases of gastric carcinoma. NDRG1 may be a candidate metastasis suppressor gene.
