中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2009年
12期
1064-1068
,共5页
曾瑶池%胡敏予%瞿树林%周光宇
曾瑤池%鬍敏予%瞿樹林%週光宇
증요지%호민여%구수림%주광우
高脂血症%红细胞%大鼠%Sprague-Dawley%番茄红素
高脂血癥%紅細胞%大鼠%Sprague-Dawley%番茄紅素
고지혈증%홍세포%대서%Sprague-Dawley%번가홍소
Hyperlipidemias%Erythrocytes%Rats%Sprague-Dawley%Lycopene
目的 研究番茄红素对高脂血症大鼠血脂及红细胞的影响.方法 成年雄性SD大鼠48只,根据总胆固醇(TC)水平、体重随机分为6组:正常对照组(A组),基础饲料喂养;高脂模型组(B组),高脂饲料喂养;阳性药物对照组(C组),高脂饲料+氟伐他汀钠10 mg·kg~(-1)·d~(-1);番茄红素D组(高脂饲料+番茄红素11 mg·kg~(-1)·d~(-1))、E组(高脂饲料+番茄红素22 mg·kg~(-1)·d~(-1))、F组(高脂饲料+番茄红素44 mg·kg~(-1)·d~(-1)),灌胃处理.各组大鼠均于实验开始第0、1、3周末取尾静脉血检测血清TC、甘油三酯(TG)等的含量.第3周末检测血红蛋白(HGB)、红细胞计数(RBC)等相关参数.结果 高脂饲料喂养1周后,大鼠形成高脂血症;实验结束,A、B、C、D、E、F组TC分别为(1.31 4-0.05)、(19.40 ±0.54)、(4.66 ±0.07)、(7.18 ±0.06)、(5.30 ±0.28)、(4.49±0.23)mmol/L(F=4395.72,P=0.00);TG分别为(0.42 ±0.01)、(2.29±0.42)、(0.69 ±0.03)、(1.10 ±0.05)、(0.63 ±0.02)、(0.62 ±0.04)mmol/L(F=127.26,P=0.00);HGB分别为(143.13 ±6.33)、(112.63 ±2.56)、(124.75 ±3.62)、(124.63 ±7.78)、(132.38 ±6.41)、(142.13 ±5.54)g/L(F=34.14,P=0.00);RBC分别为(6.75 ±0.60)× 10~(12)/L、(5.08 ±0.75)×10~(12)/L、(7.14±0.82)×10~(12)/L、(5.94 ±1.09)× 10~(12)/L、(6.18 ±0.36)× 10~(12)/L、(7.31 ±0.58)× 10~(12)/L(F=10.35.P=0.00).结论 番茄红素可能通过调节血脂和抗氧化而发挥其对红细胞的保护作用.
目的 研究番茄紅素對高脂血癥大鼠血脂及紅細胞的影響.方法 成年雄性SD大鼠48隻,根據總膽固醇(TC)水平、體重隨機分為6組:正常對照組(A組),基礎飼料餵養;高脂模型組(B組),高脂飼料餵養;暘性藥物對照組(C組),高脂飼料+氟伐他汀鈉10 mg·kg~(-1)·d~(-1);番茄紅素D組(高脂飼料+番茄紅素11 mg·kg~(-1)·d~(-1))、E組(高脂飼料+番茄紅素22 mg·kg~(-1)·d~(-1))、F組(高脂飼料+番茄紅素44 mg·kg~(-1)·d~(-1)),灌胃處理.各組大鼠均于實驗開始第0、1、3週末取尾靜脈血檢測血清TC、甘油三酯(TG)等的含量.第3週末檢測血紅蛋白(HGB)、紅細胞計數(RBC)等相關參數.結果 高脂飼料餵養1週後,大鼠形成高脂血癥;實驗結束,A、B、C、D、E、F組TC分彆為(1.31 4-0.05)、(19.40 ±0.54)、(4.66 ±0.07)、(7.18 ±0.06)、(5.30 ±0.28)、(4.49±0.23)mmol/L(F=4395.72,P=0.00);TG分彆為(0.42 ±0.01)、(2.29±0.42)、(0.69 ±0.03)、(1.10 ±0.05)、(0.63 ±0.02)、(0.62 ±0.04)mmol/L(F=127.26,P=0.00);HGB分彆為(143.13 ±6.33)、(112.63 ±2.56)、(124.75 ±3.62)、(124.63 ±7.78)、(132.38 ±6.41)、(142.13 ±5.54)g/L(F=34.14,P=0.00);RBC分彆為(6.75 ±0.60)× 10~(12)/L、(5.08 ±0.75)×10~(12)/L、(7.14±0.82)×10~(12)/L、(5.94 ±1.09)× 10~(12)/L、(6.18 ±0.36)× 10~(12)/L、(7.31 ±0.58)× 10~(12)/L(F=10.35.P=0.00).結論 番茄紅素可能通過調節血脂和抗氧化而髮揮其對紅細胞的保護作用.
목적 연구번가홍소대고지혈증대서혈지급홍세포적영향.방법 성년웅성SD대서48지,근거총담고순(TC)수평、체중수궤분위6조:정상대조조(A조),기출사료위양;고지모형조(B조),고지사료위양;양성약물대조조(C조),고지사료+불벌타정납10 mg·kg~(-1)·d~(-1);번가홍소D조(고지사료+번가홍소11 mg·kg~(-1)·d~(-1))、E조(고지사료+번가홍소22 mg·kg~(-1)·d~(-1))、F조(고지사료+번가홍소44 mg·kg~(-1)·d~(-1)),관위처리.각조대서균우실험개시제0、1、3주말취미정맥혈검측혈청TC、감유삼지(TG)등적함량.제3주말검측혈홍단백(HGB)、홍세포계수(RBC)등상관삼수.결과 고지사료위양1주후,대서형성고지혈증;실험결속,A、B、C、D、E、F조TC분별위(1.31 4-0.05)、(19.40 ±0.54)、(4.66 ±0.07)、(7.18 ±0.06)、(5.30 ±0.28)、(4.49±0.23)mmol/L(F=4395.72,P=0.00);TG분별위(0.42 ±0.01)、(2.29±0.42)、(0.69 ±0.03)、(1.10 ±0.05)、(0.63 ±0.02)、(0.62 ±0.04)mmol/L(F=127.26,P=0.00);HGB분별위(143.13 ±6.33)、(112.63 ±2.56)、(124.75 ±3.62)、(124.63 ±7.78)、(132.38 ±6.41)、(142.13 ±5.54)g/L(F=34.14,P=0.00);RBC분별위(6.75 ±0.60)× 10~(12)/L、(5.08 ±0.75)×10~(12)/L、(7.14±0.82)×10~(12)/L、(5.94 ±1.09)× 10~(12)/L、(6.18 ±0.36)× 10~(12)/L、(7.31 ±0.58)× 10~(12)/L(F=10.35.P=0.00).결론 번가홍소가능통과조절혈지화항양화이발휘기대홍세포적보호작용.
Objective To study the effect of lycopene on red blood cell and the level of blood lipid. Methods According to the level of serum total cholesterol and weight,forty-eight adult male SD rats were divided randomly into six groups; normal control (group A) ,fed by normal feed; hyperlipidemia group cholesterol(TC) and total triglyceride(TG) were measured at the end of 0,1,3 weeks of the study by taking samples from tail vein. At the end of the experiment, RBC and HCB were measured. Results After the rats were fed with high-fat feed for a week, models of hyperlipidemia rats were established. At the end of 3 weeks,TC of group A,B,C,D,E and F were (1.31 ±0. 05), (19.40 ±0. 54) , (4. 66 ±0. 07), (7. 18 ±0. 06), (5. 30 ±0.28), (4.49 ± 0. 23) mmol/L( F = 4395. 72, P = 0.00), respectively; and TG were (0.42 ±0.01),(2. 29 ±0.42), (0.69 ±0.03),(1. 10 ±0.05),(0.63 ±0. 02), (0. 62 ±0.04) mmol/L(F =127. 26,P = 0. 00), respectively; HGB were (143. 13 ± 6. 33 h (112. 63 ± 2. 56), (124. 75 ± 3. 62 ),(124. 63 ±7. 78) , (132. 38 ±6. 41), (142. 13 ±5. 54)g/L( F = 34. 14,P =0. 00),respectively;RBC were (6. 75 ±0.60) ×10~(12)/L,(5.08±0.75) × 10~(12)/L, (7. 14 ± 0. 82) × 10~(12)/L, (5. 94 ± 1. 09) × 10~(12)/L, (6. 18 ±0.36) × 10~(12)/L and (7.31 ±0.58) × 10~(12)/L ( F= 10. 35, P= 0. 00), respectively. Conclusion Lycopene have some protective effects on red blood cells of the hyperlipidemic rats by regulating the blood lipid and antioxidant.
