国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
6期
548-550
,共3页
流产,习惯性%免疫疗法,主动%治疗
流產,習慣性%免疫療法,主動%治療
유산,습관성%면역요법,주동%치료
Abortion,habitual%Immunotherapy,active%Remedy
目的 探讨细胞免疫功能的变化与原因不明习惯性流产(UHA)的发生及主动免疫治疗机制的关系.方法 用流式细胞仪测定并比较66例UHA患者和30例健康已生育妇女(NF组)及30例主动免疫治疗后的UHA患者外周血CD3+、CD4+、CD8+、CD16+CD56+细胞亚群百分率及CD4+/CD8+的比值;同时,比较采用主动免疫治疗30例和未采用主动免疫治疗的36例UHA患者再次妊娠成功率.结果 UHA患者与NF组比较,血中CD3+、CD16+CD56+细胞的百分率及CD4+/CD8+比值增高,差异有统计学意义(P＜0.050).主动免疫后CD3+、CD16+CD56+细胞的百分率及CD4+/CD8+比值下降(P＜0.050).主动免疫治疗组的再次妊娠成功率为92.86%,未主动免疫治疗组29.03%,P＜0.001.结论 淋巴细胞亚群比例的改变与UHA的发生有关,主动免疫治疗可调节异常的细胞免疫功能,有利于再次妊娠成功率的提高.
目的 探討細胞免疫功能的變化與原因不明習慣性流產(UHA)的髮生及主動免疫治療機製的關繫.方法 用流式細胞儀測定併比較66例UHA患者和30例健康已生育婦女(NF組)及30例主動免疫治療後的UHA患者外週血CD3+、CD4+、CD8+、CD16+CD56+細胞亞群百分率及CD4+/CD8+的比值;同時,比較採用主動免疫治療30例和未採用主動免疫治療的36例UHA患者再次妊娠成功率.結果 UHA患者與NF組比較,血中CD3+、CD16+CD56+細胞的百分率及CD4+/CD8+比值增高,差異有統計學意義(P＜0.050).主動免疫後CD3+、CD16+CD56+細胞的百分率及CD4+/CD8+比值下降(P＜0.050).主動免疫治療組的再次妊娠成功率為92.86%,未主動免疫治療組29.03%,P＜0.001.結論 淋巴細胞亞群比例的改變與UHA的髮生有關,主動免疫治療可調節異常的細胞免疫功能,有利于再次妊娠成功率的提高.
목적 탐토세포면역공능적변화여원인불명습관성유산(UHA)적발생급주동면역치료궤제적관계.방법 용류식세포의측정병비교66례UHA환자화30례건강이생육부녀(NF조)급30례주동면역치료후적UHA환자외주혈CD3+、CD4+、CD8+、CD16+CD56+세포아군백분솔급CD4+/CD8+적비치;동시,비교채용주동면역치료30례화미채용주동면역치료적36례UHA환자재차임신성공솔.결과 UHA환자여NF조비교,혈중CD3+、CD16+CD56+세포적백분솔급CD4+/CD8+비치증고,차이유통계학의의(P＜0.050).주동면역후CD3+、CD16+CD56+세포적백분솔급CD4+/CD8+비치하강(P＜0.050).주동면역치료조적재차임신성공솔위92.86%,미주동면역치료조29.03%,P＜0.001.결론 림파세포아군비례적개변여UHA적발생유관,주동면역치료가조절이상적세포면역공능,유리우재차임신성공솔적제고.
Objective To explore the relationship between the changes in cellular immunity and the causes of unexplained habitual abortion(UHA)as well as the mechanism of active immunotherapy on UHA patients.Methods T-lymphocyte and natural killer(NK)cell subsets(CD3+%,CD4+%,CD8+%,CD16+CD56+% and CD4+/CD8+ ratio)of peripheral blood were detected by applying flow cytometry and compared in 66 cases of UHA(UHA group,including 30 cases receiving active immunotherapy and 36 untreated UHA cases)and 30 cases of healthy fertile women(healthy control group).The re-pregnancy achievement ratio was compared between 30 treated UHA cases and 36 untreated UHA cases.Results The percentages of CD31+ and CD16+ CD56+ cells as well as CD4+/CD8+ ratio were significantly higher in UHA group than those of healthy control group(P＜0.050).As compared with those of untreated UHA subgroup,the percentages of CD3+ and CD16+ CD56+ cells as well as CD4+/CD8+ ratio were significantly lower(P＜0.050),while the re-pregnancy achievement ratio was higher(92.86% vs 05 29.03%,P＜0.001).Conclusion The changes in T-lymphocyte and NK cell subsets have something to do with occurrence of UHA.Active immunotherapy can regulate the cellular immune function and improve the re-pregnancy achievement ratio effectively.
