CAJ | 학술논문

目的：研究同型半胱氨酸与脑梗死的相关性,为脑梗死的防治提供依据。方法选择在我院神经内科住院的脑梗死患者200例作为观察组,并选择同期在我院行健康体检者100例作为对照组,其中观察组依NIHSS评分再分轻、中、重度脑功能缺损组,采用全自动生化分析仪检测研究对象血浆同型半胱氨酸水平,并进行分析和比较。结果观察组血浆同型半胱氨酸为(19.01±2.31)μmol/L、对照组为(11.23±2.91)μmol/L,两组比较差异具有统计学意义(P<0.05)。轻、中、重度脑功能缺损组血浆同型半胱氨酸水平分别为(14.82±3.22)μmol/L、(18.21±3.14)μmol/L、(23.99±4.05)μmol/L,不同脑功能缺损程度组间血浆同型半胱氨酸比较差异具有统计学意义(P<0.05)。结论血浆同型半胱氨酸水平可能与脑梗死的发生、发展相关,血浆同型半胱氨酸浓度测定对脑梗死患者病情严重程度的判断有一定的指导意义。
목적：연구동형반광안산여뇌경사적상관성,위뇌경사적방치제공의거。방법선택재아원신경내과주원적뇌경사환자200례작위관찰조,병선택동기재아원행건강체검자100례작위대조조,기중관찰조의NIHSS평분재분경、중、중도뇌공능결손조,채용전자동생화분석의검측연구대상혈장동형반광안산수평,병진행분석화비교。결과관찰조혈장동형반광안산위(19.01±2.31)μmol/L、대조조위(11.23±2.91)μmol/L,량조비교차이구유통계학의의(P<0.05)。경、중、중도뇌공능결손조혈장동형반광안산수평분별위(14.82±3.22)μmol/L、(18.21±3.14)μmol/L、(23.99±4.05)μmol/L,불동뇌공능결손정도조간혈장동형반광안산비교차이구유통계학의의(P<0.05)。결론혈장동형반광안산수평가능여뇌경사적발생、발전상관,혈장동형반광안산농도측정대뇌경사환자병정엄중정도적판단유일정적지도의의。
Objective To study the relativity between hyperhomocysteine and cerebral infarction,provid scientific basis for prevention and treatment.Methods 200 patients with cerebral infarction (observation group)and 100 health people (con-trol group)were selected,the patients in the observation group were sub-diveded into the mild,the moderate,the severe group according to NIHSS score,the level of plasma homocysteine was detected by automatic biochemical analyzer and ana-lysed.Results The level of plasma homocysteine in the observation group [(19.01±2.31)μmol/L]was significantly higher compared with the control group [(11.23±2.91)μmol/L](P<0.05).The level of plasma homocysteine in the mild,mod-erate,severe group were (14.82±3.22),(18.21±3.14),(23.99±4.05)μmol/L,respectively,there was significant differ-ence among these 3 groups (P<0.05).Conclusion The level of plasma homocysteine might relate to the occurrence and de-velopment of cerebral infarction,determination of plasma homocysteine concentration could be help to j udge the severity of cerebral infarction.