CAJ | 학술논문

目的:探讨基质金属蛋白酶-3(MMP-3)、高敏C-反应蛋白(hs-CRP)与颈动脉粥样硬化和急性脑梗死的关系.方法:64例首次发病的脑梗死患者和20例健康体检者,应用酶联免疫双抗体夹心法测定血清MMP-3浓度,免疫散射比浊法测定血清hs-CRP浓度.应用颈动脉超声检测颈动脉内膜状况,并对急性脑梗死患者进行神经功能缺损评分.结果:急性脑梗死患者血清MMP-3和hs-CRP浓度显著高于正常对照组(P＜0.01).不稳定斑块组(混合斑块组、软斑组)血清MMP-3和hs-CRP浓度显著高于稳定斑块组(硬化斑块组)和内膜毛糙组(P＜0.01).血清MMP-3和hs-CRP浓度分别与急性脑梗死患者神经功能缺损评分呈正相关.结论:急性脑梗死患者血清MMP-3和hs-CRP水平可以反映颈动脉斑块的性质和稳定性,是临床了解脑梗死严重程度的重要指标.
목적:탐토기질금속단백매-3(MMP-3)、고민C-반응단백(hs-CRP)여경동맥죽양경화화급성뇌경사적관계.방법:64례수차발병적뇌경사환자화20례건강체검자,응용매련면역쌍항체협심법측정혈청MMP-3농도,면역산사비탁법측정혈청hs-CRP농도.응용경동맥초성검측경동맥내막상황,병대급성뇌경사환자진행신경공능결손평분.결과:급성뇌경사환자혈청MMP-3화hs-CRP농도현저고우정상대조조(P＜0.01).불은정반괴조(혼합반괴조、연반조)혈청MMP-3화hs-CRP농도현저고우은정반괴조(경화반괴조)화내막모조조(P＜0.01).혈청MMP-3화hs-CRP농도분별여급성뇌경사환자신경공능결손평분정정상관.결론:급성뇌경사환자혈청MMP-3화hs-CRP수평가이반영경동맥반괴적성질화은정성,시림상료해뇌경사엄중정도적중요지표.
Objective:To investigate the relationships between matrix metalloproteinase-3 (MMP-3),high-sensitivity C-reactive protein(hs-CRP)and carotid atherosclerosis and acute cerebral infarction.Methods: Sixty-four patients with the first ever cerebral infarction and 20 normal control subjects were selected.Their serum MMP-3 levels were determined by double antibody enzyme-linked immunosorbent assays,and serum hs-CRP levels were measured by immunonephelometric assay.Their carotid intima-media thicknesses were assessed by carotid ultrasonography,and neurological deficit scores were performed in patients with acute cerebral infarction.Results:The levels of serum MMP-3 and hs-CRP in patients with acute cerebral infarction were significantly higher than those in the normal control group(P＜0.01).The levels of serum MMP-3 and hs-CRP in unstable plaque group(mixed plaque group,soft plaque group)were significantly higher than those in stable plaque group(hard plaque group)and rough intima group(P＜0.01).The levels of serum MMP-3 and hs-CRP were positively correlated with the neurological deficit scores respectively in patients with acute cerebral infarction. Conclusions:The levels of serum MMP-3 and hs-CRP in patients with acute cerebral infarction may reflect the character and stability of carotid artery plaque,and they are the important indexes in understanding the severity of cerebral infarction in clinical practice.