白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2011年
5期
289-291
,共3页
非霍奇金淋巴瘤%胆碱酯酶%乳酸脱氢酶%β2微球蛋白
非霍奇金淋巴瘤%膽堿酯酶%乳痠脫氫酶%β2微毬蛋白
비곽기금림파류%담감지매%유산탈경매%β2미구단백
Non-Hodgkin lymphoma%Cholinesterase%Lactic dehydrogenate%β2-Microglobulin
目的 探讨非霍奇金淋巴瘤(NHL)患者血清胆碱酯酶(CHE)表达水平与患者临床特征及血清乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)表达的相关性.方法 分别采用速率法、免疫法检测74例NHL患者血清CHE、LDH、β2-MG值,根据血清CHE均值5750 U/L分成低CHE水平组38例与高CHE水平组36例,比较两组患者的临床特征及LDH、β2-MG水平.结果 低CHE水平组与高CHE水平组血清CHE、LDH、β2-MG表达水平差异有统计学意义[(3714.2±1207.1)U/L、(435.7±36.4.4)U/L、(4.3±2.9)mg/L;(7898.2±1550.5)U/L、(247.4±134.8)U/L、(2.7±1.2)mg/L](t=10.510,P=0.000;t=2.969,P=0.005;t=3.043,P=0.004);两组年龄、病理类型、WBC、Plt差异无统计学意义(t=0.166,P=0.868;x2=0.751,P=0.386;t=1.626,P=0.111;t=1.987,P=0.056);两组性别、Ann Arbor分期有明显不同,低CHE水平组以男性(x2=5.432,P=0.020)、Ann Arbor Ⅲ～Ⅳ期(x2=9.394,P=0.024)患者为主.低CHE水平组血红蛋白含量[(97.6±25.8)g/L胝于高CHE水平组[(113.4±15.2)g/L],差异有统计学意义(t=3.230,P=0.002).结论 NHL患者CHE低活性与年龄、病理类型、WBC、Plt无关,与男性、Ann ArborⅢ/Ⅳ期、贫血、LDH、β2-MG高表达相关.
目的 探討非霍奇金淋巴瘤(NHL)患者血清膽堿酯酶(CHE)錶達水平與患者臨床特徵及血清乳痠脫氫酶(LDH)、β2-微毬蛋白(β2-MG)錶達的相關性.方法 分彆採用速率法、免疫法檢測74例NHL患者血清CHE、LDH、β2-MG值,根據血清CHE均值5750 U/L分成低CHE水平組38例與高CHE水平組36例,比較兩組患者的臨床特徵及LDH、β2-MG水平.結果 低CHE水平組與高CHE水平組血清CHE、LDH、β2-MG錶達水平差異有統計學意義[(3714.2±1207.1)U/L、(435.7±36.4.4)U/L、(4.3±2.9)mg/L;(7898.2±1550.5)U/L、(247.4±134.8)U/L、(2.7±1.2)mg/L](t=10.510,P=0.000;t=2.969,P=0.005;t=3.043,P=0.004);兩組年齡、病理類型、WBC、Plt差異無統計學意義(t=0.166,P=0.868;x2=0.751,P=0.386;t=1.626,P=0.111;t=1.987,P=0.056);兩組性彆、Ann Arbor分期有明顯不同,低CHE水平組以男性(x2=5.432,P=0.020)、Ann Arbor Ⅲ～Ⅳ期(x2=9.394,P=0.024)患者為主.低CHE水平組血紅蛋白含量[(97.6±25.8)g/L胝于高CHE水平組[(113.4±15.2)g/L],差異有統計學意義(t=3.230,P=0.002).結論 NHL患者CHE低活性與年齡、病理類型、WBC、Plt無關,與男性、Ann ArborⅢ/Ⅳ期、貧血、LDH、β2-MG高錶達相關.
목적 탐토비곽기금림파류(NHL)환자혈청담감지매(CHE)표체수평여환자림상특정급혈청유산탈경매(LDH)、β2-미구단백(β2-MG)표체적상관성.방법 분별채용속솔법、면역법검측74례NHL환자혈청CHE、LDH、β2-MG치,근거혈청CHE균치5750 U/L분성저CHE수평조38례여고CHE수평조36례,비교량조환자적림상특정급LDH、β2-MG수평.결과 저CHE수평조여고CHE수평조혈청CHE、LDH、β2-MG표체수평차이유통계학의의[(3714.2±1207.1)U/L、(435.7±36.4.4)U/L、(4.3±2.9)mg/L;(7898.2±1550.5)U/L、(247.4±134.8)U/L、(2.7±1.2)mg/L](t=10.510,P=0.000;t=2.969,P=0.005;t=3.043,P=0.004);량조년령、병리류형、WBC、Plt차이무통계학의의(t=0.166,P=0.868;x2=0.751,P=0.386;t=1.626,P=0.111;t=1.987,P=0.056);량조성별、Ann Arbor분기유명현불동,저CHE수평조이남성(x2=5.432,P=0.020)、Ann Arbor Ⅲ～Ⅳ기(x2=9.394,P=0.024)환자위주.저CHE수평조혈홍단백함량[(97.6±25.8)g/L지우고CHE수평조[(113.4±15.2)g/L],차이유통계학의의(t=3.230,P=0.002).결론 NHL환자CHE저활성여년령、병리류형、WBC、Plt무관,여남성、Ann ArborⅢ/Ⅳ기、빈혈、LDH、β2-MG고표체상관.
Objective To study the relationship between the serum level of cholinesterase (CHE) and patient's clinical characteristics and serum levels of lactic dehydrogenate(LDH) and β2-microglobulin (β2-MG) in non-Hodgkin lymphoma(NHL) patients. Methods The levels of CHE, LDH, β2-MG were detected with rate method and immunoassay respectively in 74 patients, and then these patients were divided into low (38 patients) and high level groups (36 patients) according to the serum CHE levels, compared with clinical characteristics and serum levels of LDH and β2-MG between the two groups. Results There were a significant difference in serum levels of CHE, LDH, β2-MG between the low and the high CHE level group [(3714.2 ±1207.1) U/L, (435.7±364.4) U/L, (4.3±2.9) mg/L; (7898.2± 1550.5) U/L, (247.4±134.8) U/L, (2.7±1.2) mg/L, respectively] (t =10.510, P =0.000; t =2.969, P =0.005; t =3.043, P =0.004, respectively). There were no statically significance in age, pathology type, leukocyte and platelet between the low and high serum CHE level groups (t =0.166, P =0.868; x2 =0.751, P=0.386; t =1.626, P=0.111; t =1.987, P=0.056, respectively). Patients with low CHE level group were mostly in Ann Arbor Ⅲ-Ⅳ period (x2 =9.394, P =0.024) and mostly male patients compared with the high CHE level group patients (x2 =5.432, P =0.020). The quantity of hemoglobin in the low CHE level group(97.6±25.8) g/L were lower than that of the high level group (113.4±15.2) g/L (t = 3.230, P =0.002). Conclusion The low CHE level was not correlated with age, pathology type, leukocyte and platelet, but was related with male, Ann Arbor Ⅲ-Ⅳ period, anemia, and higher expression of LDH, β2-MG.
