中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2009年
4期
589-590
,共2页
胡学军%梁鸿健%关日邦%陈焕英
鬍學軍%樑鴻健%關日邦%陳煥英
호학군%량홍건%관일방%진환영
红斑狼疮,系统性%甲氨蝶呤%泼尼松
紅斑狼瘡,繫統性%甲氨蝶呤%潑尼鬆
홍반랑창,계통성%갑안접령%발니송
Lupus erythematosus,systemic%Prednisone%Methotrexate
目的 评估甲氨蝶呤(MTX)治疗轻、中度活动系统性红斑狼疮(SLE)的疗效.方法 专科门诊随诊患者分为:A组,MTX加小剂量激素组(泼尼松10 mg/d)28例;B组,中等剂量激索组(泼尼松30 mg/d)20例,观察指标包括SLE疾病活动指数评分(SLEDAI)、激素减至少剂量维持治疗时病情复发情况及药物不良反应.结果 A组积分由治疗前的(9.4±2.1)降至(4.1±0.9),B组由(8.6±2.5)降至(4.0±1.0).两组治疗前后相比疗效差异显著(P<0.01),但A、B两组间疗效差异无统计学意义(P>0.25),激素减量至10 mg/d维持后B组有8例出现病情反复,A组在总观察期有3例病情反复,两组对比差异有统计学意义(P<0.025).A组不良反应主要是胃肠道反应,B组以库兴综合征为主.结论 MTX对轻中症SLE治疗有效,加用MTX可减少激素用量,防止长期使用偏大量激素引起相关不良反应.
目的 評估甲氨蝶呤(MTX)治療輕、中度活動繫統性紅斑狼瘡(SLE)的療效.方法 專科門診隨診患者分為:A組,MTX加小劑量激素組(潑尼鬆10 mg/d)28例;B組,中等劑量激索組(潑尼鬆30 mg/d)20例,觀察指標包括SLE疾病活動指數評分(SLEDAI)、激素減至少劑量維持治療時病情複髮情況及藥物不良反應.結果 A組積分由治療前的(9.4±2.1)降至(4.1±0.9),B組由(8.6±2.5)降至(4.0±1.0).兩組治療前後相比療效差異顯著(P<0.01),但A、B兩組間療效差異無統計學意義(P>0.25),激素減量至10 mg/d維持後B組有8例齣現病情反複,A組在總觀察期有3例病情反複,兩組對比差異有統計學意義(P<0.025).A組不良反應主要是胃腸道反應,B組以庫興綜閤徵為主.結論 MTX對輕中癥SLE治療有效,加用MTX可減少激素用量,防止長期使用偏大量激素引起相關不良反應.
목적 평고갑안접령(MTX)치료경、중도활동계통성홍반랑창(SLE)적료효.방법 전과문진수진환자분위:A조,MTX가소제량격소조(발니송10 mg/d)28례;B조,중등제량격색조(발니송30 mg/d)20례,관찰지표포괄SLE질병활동지수평분(SLEDAI)、격소감지소제량유지치료시병정복발정황급약물불량반응.결과 A조적분유치료전적(9.4±2.1)강지(4.1±0.9),B조유(8.6±2.5)강지(4.0±1.0).량조치료전후상비료효차이현저(P<0.01),단A、B량조간료효차이무통계학의의(P>0.25),격소감량지10 mg/d유지후B조유8례출현병정반복,A조재총관찰기유3례병정반복,량조대비차이유통계학의의(P<0.025).A조불량반응주요시위장도반응,B조이고흥종합정위주.결론 MTX대경중증SLE치료유효,가용MTX가감소격소용량,방지장기사용편대량격소인기상관불량반응.
Objective To investigate the curative effect of methotrexate in treating systemic lupus erythema-tosus(SLE). Methods The chosen outpatients were divided into 2 groups,group A(28 cases) :MTX combined with small dosage of prednisone (prednlsone 10mg/d) ; group B (20 cuses) : medium dosage of prednisone (prednisone 30rag/d). Observation includes SLE disease activity index(SLEDAI) ,relapse while dosage of prednisone was reduced to small amount and drug side effects. Results The SLEDAI score of group A was reduced from (9.4±2.1) to (4.1±0.9) ,and group B from (8.6±2.5) to (4.0±1.0). Compared the result of before and after treatment be-twcen the two groups, the curative effect is obvious (P<0.01). However, there was no significant difference of efficacy between the two groups(P>0.25). While dosage of prednisone was reduced to 10mg/d ,there were 8 cases of relapse in group B,and only 3 cases in group A during the entire observation period. The difference is significant (P<0.025). The side effect of group A is gastrointestinal reaction and for B is mainly the cushing syndrome. Conclusion MTX is an effective treatment fw the light and medium activity SLE,and can reduce the dose of prednisone, prevent long-term using large dose of prednisone which will cause side effect.
