中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2008年
8期
591-593
,共3页
胡长春%谢文婷%LI Ting%叶洪青%CHEN Zhi-yun%朱婉儿
鬍長春%謝文婷%LI Ting%葉洪青%CHEN Zhi-yun%硃婉兒
호장춘%사문정%LI Ting%협홍청%CHEN Zhi-yun%주완인
应激,心理学%凋亡调节蛋白质类
應激,心理學%凋亡調節蛋白質類
응격,심이학%조망조절단백질류
Stress,psychosocial%Apoptosis regulatory proteins
目的 探讨老年人外周血清可溶性凋亡相关因子(sFas)及其配体(FasL)水平的变化及其意义. 方法 采用双抗体夹心酶联免疫吸附法(ELISA),检测50例老年人血清sFas和FasL水平,与非老年人进行对照研究,并分析老年人血清sFas、FasL水平与心理应激以及应对方式之间的关系. 结果 老年组血清sFas水平为(10.6±2.8)μg/L,明显高于非老年组(7.5±2.2)μg/L,差异有统计学意义(P<0.01);FasL水平为(34.9±19.8)μg/L,明显低于非老年组(52.9±16.1)μg/L,差异有统计学意义(P<0.01).老年组sFas水平与心理应激成正相关(r=0.453,P<0.01);与积极应对方式成负相关(r=-0.535,P<0.01). 结论 老年人血清sFas、FasL水平异常,提示增龄增加了Fas介导的细胞凋亡,且与个体心理应激状况、应对方式有一定关系,这可能提示慢性应激是老年人免疫衰老的重要原因之一;同时老年人体内还可能存在着Fas/FasL的动态平衡机制.
目的 探討老年人外週血清可溶性凋亡相關因子(sFas)及其配體(FasL)水平的變化及其意義. 方法 採用雙抗體夾心酶聯免疫吸附法(ELISA),檢測50例老年人血清sFas和FasL水平,與非老年人進行對照研究,併分析老年人血清sFas、FasL水平與心理應激以及應對方式之間的關繫. 結果 老年組血清sFas水平為(10.6±2.8)μg/L,明顯高于非老年組(7.5±2.2)μg/L,差異有統計學意義(P<0.01);FasL水平為(34.9±19.8)μg/L,明顯低于非老年組(52.9±16.1)μg/L,差異有統計學意義(P<0.01).老年組sFas水平與心理應激成正相關(r=0.453,P<0.01);與積極應對方式成負相關(r=-0.535,P<0.01). 結論 老年人血清sFas、FasL水平異常,提示增齡增加瞭Fas介導的細胞凋亡,且與箇體心理應激狀況、應對方式有一定關繫,這可能提示慢性應激是老年人免疫衰老的重要原因之一;同時老年人體內還可能存在著Fas/FasL的動態平衡機製.
목적 탐토노년인외주혈청가용성조망상관인자(sFas)급기배체(FasL)수평적변화급기의의. 방법 채용쌍항체협심매련면역흡부법(ELISA),검측50례노년인혈청sFas화FasL수평,여비노년인진행대조연구,병분석노년인혈청sFas、FasL수평여심리응격이급응대방식지간적관계. 결과 노년조혈청sFas수평위(10.6±2.8)μg/L,명현고우비노년조(7.5±2.2)μg/L,차이유통계학의의(P<0.01);FasL수평위(34.9±19.8)μg/L,명현저우비노년조(52.9±16.1)μg/L,차이유통계학의의(P<0.01).노년조sFas수평여심리응격성정상관(r=0.453,P<0.01);여적겁응대방식성부상관(r=-0.535,P<0.01). 결론 노년인혈청sFas、FasL수평이상,제시증령증가료Fas개도적세포조망,차여개체심리응격상황、응대방식유일정관계,저가능제시만성응격시노년인면역쇠로적중요원인지일;동시노년인체내환가능존재착Fas/FasL적동태평형궤제.
Objective To investigate the changes and the clinical significance of serum concentration of soluble Fas (sFas) and Fas ligand (FasL) in the elderly. Methods Fifty elderly subjects and forty-seven adults were recruited. Serum concentration of sFas and EasL were detected by enzyme-linked immunosorbent assay (ELISA) . Psychosocial stress and coping styles were also evaluated. Results The sFas level of the elderly was significantly higher than that in control group,whereas the EasL level was decreased with ageing (P<0.01). A positive correlation between sFas level and psychosocial stress, and a negative correlation between sFas level and positive coping were also found (all P<0. 05). Conclusions Age-related changes occur in serum sEas and EasL levels.The interaction of sFas/FasL system with psychosocial stress and coping styles seems to play important roles in immunosenescence. Our results also suggest that during aging a subtle balance between sFas and FasL could exist.