CAJ | 학술논문

目的探讨糖化血清白蛋白水平(GA)与冠心病(CAD)的关系.方法入选2008年4月至2010年5月上海第六人民医院306例接受冠脉造影检查的患者(男201例,女105例),年龄38 ～ 86岁.CAD的诊断采用冠脉造影的金标准；代谢综合征采用2007年中国成人血脂异常防治指南中关于代谢综合征的诊断标准.结果 (1) 306例研究对象中,227例患者(74.2％)为CAD,其餐后2h血糖、GA、糖化血红蛋白显著高于非CAD组(均P＜0.05).(2)亚组分析见到,正常糖耐量亚组CAD者的GA水平高于非CAD者[(15.0±2.1)％比(13.3±1.7)％,P＜0.01],且冠脉单支病变者的GA水平[(14.8±2.1)％比(13.3±1.7)％,P＜0.05]及多支病变者[(15.1±2.1)％比(13.3±1.7)％,P＜0.05]均高于无病变者.在高血糖亚组中亦得出相似结果.(3)Logistic回归分析显示,校正CAD传统的危险因素后,无论在总人群、正常糖耐量亚组还是在高血糖亚组中,GA均为CAD的独立危险因素(P＜0.05).结论 CAD患者GA水平明显升高,GA不仅在高血糖人群的CAD发病中起重要作用,而且在正常糖耐量人群中亦是CAD的独立危险因素.
목적 탐토당화혈청백단백수평(GA)여관심병(CAD)적관계.방법 입선2008년4월지2010년5월상해제륙인민의원306례접수관맥조영검사적환자(남201례,녀105례),년령38 ～ 86세.CAD적진단채용관맥조영적금표준；대사종합정채용2007년중국성인혈지이상방치지남중관우대사종합정적진단표준.결과 (1) 306례연구대상중,227례환자(74.2％)위CAD,기찬후2h혈당、GA、당화혈홍단백현저고우비CAD조(균P＜0.05).(2)아조분석견도,정상당내량아조CAD자적GA수평고우비CAD자[(15.0±2.1)％비(13.3±1.7)％,P＜0.01],차관맥단지병변자적GA수평[(14.8±2.1)％비(13.3±1.7)％,P＜0.05]급다지병변자[(15.1±2.1)％비(13.3±1.7)％,P＜0.05]균고우무병변자.재고혈당아조중역득출상사결과.(3)Logistic회귀분석현시,교정CAD전통적위험인소후,무론재총인군、정상당내량아조환시재고혈당아조중,GA균위CAD적독립위험인소(P＜0.05).결론 CAD환자GA수평명현승고,GA불부재고혈당인군적CAD발병중기중요작용,이차재정상당내량인군중역시CAD적독립위험인소.
Objective To explore the associations of the level of glycated albumin (GA) with coronary artery disease (CAD).Methods A total of 306 patients undergoing coronary angiography (CA) were collected.There were 201 males and 105 females with an age range of 38 - 86 years.CA was the major diagnostic criteria of CAD.Metabolic syndrome was diagnosed according to the Guideline on Prevention & Treatment of Blood Lipid Abnormality in Chinese Adults.Results ( 1 ) CAD was found in 227 patients (74.2％ ).The levels of 2 h postprandial glucose,GA and hemoglobin A1 c in the CAD patients were higher than those in the non-CAD counterparts ( all P ＜ 0.05 ).(2) In the subgroup of normal glucose tolerance ( NGR),the CAD patients had a higher level of GA than the non-CAD patients ( ( 15.0 ± 2.1 ) ％ vs (13.3±1.7)％,P＜0.01).And the level of GA was higher in the patients with 1-vessel ((14.8 ±2.1)％ vs (13.3±1.7)％,P＜0.05) and multi-vessel lesions ((15.1 ±2.1)％ vs (13.3±1.7)％,P ＜ 0.05) than that in the non-CAD counterparts ( all P ＜ 0.05 ). Similar results were obtained in the hyperglycemia subgroup. (3) Logistic regression demonstrated that the level of GA was independently correlated with CAD after adjusting other traditional factors among all subjects,NGR and hyperglycemia subgroup.Conclusions The serum level of GA becomes significantly elevated the CAD patients.And it is an independent risk factor of CAD in both hyperglycemic and NGR patients.