CAJ | 학술논문

疟疾是世界上危害人类健康最严重的感染性疾病之一.随着抗疟药物的广泛使用,疟原虫抗药性问题日趋严重.开展疟原虫药物抗性机制的研究,有助于开发新的药物以及制定用药策略.采用疟原虫转基因的方法能够从分子水平证实抗性基因与药物敏感的相关性以及基因突变在药物抗性产生中所起的作用.该文综述了疟原虫转基因技术在氯喹和磺胺多辛-乙胺嘧啶药物抗性机制研究中的应用.
학질시세계상위해인류건강최엄중적감염성질병지일.수착항학약물적엄범사용,학원충항약성문제일추엄중.개전학원충약물항성궤제적연구,유조우개발신적약물이급제정용약책략.채용학원충전기인적방법능구종분자수평증실항성기인여약물민감적상관성이급기인돌변재약물항성산생중소기적작용.해문종술료학원충전기인기술재록규화광알다신-을알밀정약물항성궤제연구중적응용.
Malaria is one of the leading infectious diseases in the world. The acquisition and spread of drug-resistant parasite arose gradually since widely utilization of antimalarial drugs. Investigations of the drugresistant mechanisms of malaria parasites may have advantages in developing new drug and modifying chemotherapy strategy. Introduction of transfection technologies made it possible to prove the role of candidate genes responsible for drug resistance, and the contribution of specific mutations to the resistance phenotype. This review focused on the application of transfection technologies in both Plasmodium falciparum and P. vivax to dissect the mechanisms of antimalarial drug resistance including chloroquine and sulfadoxin-pyrimethamine.