中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2010年
11期
947-950
,共4页
不宁腿综合征%帕金森病%铁蛋白质类
不寧腿綜閤徵%帕金森病%鐵蛋白質類
불저퇴종합정%파금삼병%철단백질류
Restless legs syndrome%Parkinson's disease%Ferritins
目的 了解帕金森病(PD)合并不宁腿综合征(RLS)患者的临床特点并探索RLS发病机制.方法 采用横断面对照研究.选取31例中老年PD合并RLS的患者为病例组,39例单纯PD患者为对照组,分别比较两组的病史、临床表现、合并症、实验室检查等临床资料,并设立健康对照组进一步行实验室检查比较.结果 所有RLS患者均在PD症状出现后才出现RLS症状.PD合并RLS组与单纯PD组比较,在统一帕金森评定量表-Ⅲ、汉宾尔顿焦虑及抑郁评分、匹兹堡睡眠质量指数及吞咽障碍、便秘、幻觉等合并症方面差异有统计学意义(P＜0.05),而在主要症状、简易精神状态量表、Epworth睡眠调查表评分等方面则差异无统计学意义(P＞0.05);与单纯PD组及健康对照组比较,PD合并RLS组的血清铁蛋白水平明显降低、胫神经H-反射潜伏期明显缩短(P＜0.05).结论 RLS是PD病程中出现的一种并发症.PD患者合并出现RLS可能与铁缺乏及脊髓水平抑制功能减弱有关.PD患者运动症状较严重、并发症较多时合并出现RLS的可能性相对较大.
目的 瞭解帕金森病(PD)閤併不寧腿綜閤徵(RLS)患者的臨床特點併探索RLS髮病機製.方法 採用橫斷麵對照研究.選取31例中老年PD閤併RLS的患者為病例組,39例單純PD患者為對照組,分彆比較兩組的病史、臨床錶現、閤併癥、實驗室檢查等臨床資料,併設立健康對照組進一步行實驗室檢查比較.結果 所有RLS患者均在PD癥狀齣現後纔齣現RLS癥狀.PD閤併RLS組與單純PD組比較,在統一帕金森評定量錶-Ⅲ、漢賓爾頓焦慮及抑鬱評分、匹玆堡睡眠質量指數及吞嚥障礙、便祕、幻覺等閤併癥方麵差異有統計學意義(P＜0.05),而在主要癥狀、簡易精神狀態量錶、Epworth睡眠調查錶評分等方麵則差異無統計學意義(P＞0.05);與單純PD組及健康對照組比較,PD閤併RLS組的血清鐵蛋白水平明顯降低、脛神經H-反射潛伏期明顯縮短(P＜0.05).結論 RLS是PD病程中齣現的一種併髮癥.PD患者閤併齣現RLS可能與鐵缺乏及脊髓水平抑製功能減弱有關.PD患者運動癥狀較嚴重、併髮癥較多時閤併齣現RLS的可能性相對較大.
목적 료해파금삼병(PD)합병불저퇴종합정(RLS)환자적림상특점병탐색RLS발병궤제.방법 채용횡단면대조연구.선취31례중노년PD합병RLS적환자위병례조,39례단순PD환자위대조조,분별비교량조적병사、림상표현、합병증、실험실검사등림상자료,병설립건강대조조진일보행실험실검사비교.결과 소유RLS환자균재PD증상출현후재출현RLS증상.PD합병RLS조여단순PD조비교,재통일파금삼평정량표-Ⅲ、한빈이돈초필급억욱평분、필자보수면질량지수급탄인장애、편비、환각등합병증방면차이유통계학의의(P＜0.05),이재주요증상、간역정신상태량표、Epworth수면조사표평분등방면칙차이무통계학의의(P＞0.05);여단순PD조급건강대조조비교,PD합병RLS조적혈청철단백수평명현강저、경신경H-반사잠복기명현축단(P＜0.05).결론 RLS시PD병정중출현적일충병발증.PD환자합병출현RLS가능여철결핍급척수수평억제공능감약유관.PD환자운동증상교엄중、병발증교다시합병출현RLS적가능성상대교대.
Objectives To investigate the clinical feature of Parkinson's disease (PD) with restless leg syndrome (RLS) and the pathogenesis of RLS. Methods We conducted a cross-sectional and control study. The case group concluded 31 PD with RLS patients, meanwhile 39 PD patients were selected as the control group. Clinical history, clinical manifestations, complications and laboratory examinations were compared respectively between the two groups. Results All the RLS symptoms did not appear in RLS patients until the PD symptoms came out. Significant differences were found in complications such as swallow disturbance, constipation and illusion, when we compared the two PD groups (P ＜ 0.05 ). Compared with the PD or healthy group, the level of serum ferritin and the H-reflex latency of tibial nerve were significantly decreased in PD with RLS group ( P＜0.05). Conclusions Secondary RLS is a complication of PD.Deficiency of iron and decreased inhibition function of spinal cord may lead to the occurrence of RLS in PD patients. When their motor symptoms are serious and complications are more common, PD patients are more possible to have RLS symptoms.
