CAJ | 학술논문

M2基质蛋白是A型流感病毒膜蛋白,在A型流感病毒的生命周期中,M2具有重要的生物学功能,已成为抗病毒药物研究的靶蛋白.其胞外区M2e(M2 eetodomain,M2e)为24个氨基酸残基,该片段在多病毒株中具有极高的保守性.针对M2e产生IgG型抗体能够防止流感病毒引发的死亡,减少动物模型中流感的发病率.了解有关M2e疫苗的研究进展,以及关于M2e作为A型流感疫苗靶抗原的关键问题很重要.
M2기질단백시A형류감병독막단백,재A형류감병독적생명주기중,M2구유중요적생물학공능,이성위항병독약물연구적파단백.기포외구M2e(M2 eetodomain,M2e)위24개안기산잔기,해편단재다병독주중구유겁고적보수성.침대M2e산생IgG형항체능구방지류감병독인발적사망,감소동물모형중류감적발병솔.료해유관M2e역묘적연구진전,이급관우M2e작위A형류감역묘파항원적관건문제흔중요.
Matrix protein M2 (M2) is the membrane protein of Influenza A with an extracellular domain of 24 amino acid residues, which is strongly conserved across virus strains. M2 plays an important role in the life cy-cle of the Influenza A virus and has been the target of antiviral drugs. IgG subtype antibodies directed against M2e can prevent death from influenza and reduce morbidity in animal models for influenza disease. This review summarizes the findings on M2e vaccine candidates and addresses some key questions about this Influenza A vaccine target.