中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
19期
23-25
,共3页
阿司匹林%熊脱氧胆酸%胆汁淤积,肝内
阿司匹林%熊脫氧膽痠%膽汁淤積,肝內
아사필림%웅탈양담산%담즙어적,간내
Aspirin%Ursodeoxycholic acid%Cholestasis,intrahepatic
目的 探讨阿司匹林与熊去氧胆酸治疗妊娠期肝内胆汁淤积症(ICP)的临床效果.方法 将71例确诊的ICP患者按随机数字表法分为两组:观察组(36例)给予阿司匹林与熊去氧胆酸治疗,对照组(35例)给予熊去氧胆酸治疗.观察两组生化指标、瘙痒评分及妊娠结局.结果 两组治疗后血清总胆汁酸(TBA)、总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、瘙痒评分均较治疗前明显下降(P＜0.05)；且观察组治疗后TBA、TBIL、ALT、瘙痒评分[(31.7±8.3)μmol/L、(33.9±5.8)μ mol/L、(53.1±8.4) U/L、(0.48±0.06)分]显著低于对照组[(76.2±9.2)μmol/L、(56.9±8.2)μmol/L、(80.8±10.6) U/L、(0.81±0.04)分](P＜0.05).观察组羊水污染、早产、新生儿窒息发生率均明显低于对照组[ 38.9％(14/36)比71.4％( 25/35)、11.1％(4/36)比31.4％(1 1/35)、5.6％(2/36)比22.9％( 8/35),P＜0.05].结论 熊去氧胆酸与阿司匹林联合应用可改善ICP患者的生化指标、皮肤瘙痒症状和妊娠结局.
目的 探討阿司匹林與熊去氧膽痠治療妊娠期肝內膽汁淤積癥(ICP)的臨床效果.方法 將71例確診的ICP患者按隨機數字錶法分為兩組:觀察組(36例)給予阿司匹林與熊去氧膽痠治療,對照組(35例)給予熊去氧膽痠治療.觀察兩組生化指標、瘙癢評分及妊娠結跼.結果 兩組治療後血清總膽汁痠(TBA)、總膽紅素(TBIL)、丙氨痠氨基轉移酶(ALT)、天鼕氨痠氨基轉移酶(AST)、瘙癢評分均較治療前明顯下降(P＜0.05)；且觀察組治療後TBA、TBIL、ALT、瘙癢評分[(31.7±8.3)μmol/L、(33.9±5.8)μ mol/L、(53.1±8.4) U/L、(0.48±0.06)分]顯著低于對照組[(76.2±9.2)μmol/L、(56.9±8.2)μmol/L、(80.8±10.6) U/L、(0.81±0.04)分](P＜0.05).觀察組羊水汙染、早產、新生兒窒息髮生率均明顯低于對照組[ 38.9％(14/36)比71.4％( 25/35)、11.1％(4/36)比31.4％(1 1/35)、5.6％(2/36)比22.9％( 8/35),P＜0.05].結論 熊去氧膽痠與阿司匹林聯閤應用可改善ICP患者的生化指標、皮膚瘙癢癥狀和妊娠結跼.
목적 탐토아사필림여웅거양담산치료임신기간내담즙어적증(ICP)적림상효과.방법 장71례학진적ICP환자안수궤수자표법분위량조:관찰조(36례)급여아사필림여웅거양담산치료,대조조(35례)급여웅거양담산치료.관찰량조생화지표、소양평분급임신결국.결과 량조치료후혈청총담즙산(TBA)、총담홍소(TBIL)、병안산안기전이매(ALT)、천동안산안기전이매(AST)、소양평분균교치료전명현하강(P＜0.05)；차관찰조치료후TBA、TBIL、ALT、소양평분[(31.7±8.3)μmol/L、(33.9±5.8)μ mol/L、(53.1±8.4) U/L、(0.48±0.06)분]현저저우대조조[(76.2±9.2)μmol/L、(56.9±8.2)μmol/L、(80.8±10.6) U/L、(0.81±0.04)분](P＜0.05).관찰조양수오염、조산、신생인질식발생솔균명현저우대조조[ 38.9％(14/36)비71.4％( 25/35)、11.1％(4/36)비31.4％(1 1/35)、5.6％(2/36)비22.9％( 8/35),P＜0.05].결론 웅거양담산여아사필림연합응용가개선ICP환자적생화지표、피부소양증상화임신결국.
Objective To investigate the clinical effect of aspirin and ursodeoxycholic acid on treating intrahepatic cholestasis of pregnancy (ICP).Methods Seventy-one ICP patients were divided by random digits table method into observation group (36 cases) and contol group (35 cases).Observation group was treated with aspirin and ursodeoxycholic acid.Control group was given unsodeoxycholic acid.The biochemical indicators,itching score and pregnancy outcomes of two groups were observed.Results Total bile acid (TBA),total bilirubin (TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and itching score of two groups after treatment were all significantly lower than those before treatment (P ＜0.05 ).TBA,TBIL,ALT and itching score of observation group[ (31.7 ± 8.3 ) μ mol/L,(33.9 ± 5.8 ) μ mol/L,(53.1 ± 8.4) U/L,(0.48 ± 0.06) scores] were obviously lower than those of control group [(76.2 ±9.2)μ mol/L,(56.9 ± 8.2) μmol/L,(80.8 ± 10.6) U/L,(0.81 ±0.04) scores] (P ＜0.05).The incidences of amniotic fluid contamination,premature delivery and neonatal asphyxia of observation group were significantly lower than those of control group [38.9％(14/36) vs.71.4％(25/35),11.1％(4/36) vs.31.4％( 11/35 ),5.6％ ( 2/36 ) vs.22.9％ ( 8/35 ),P ＜ 0.05 ].Conclusions The combined application of aspirin and ursodeoxycholic acid can improve the biochemical indicators,itching symptom and pregnancy outcomes.
