中华眼视光学与视觉科学杂志
中華眼視光學與視覺科學雜誌
중화안시광학여시각과학잡지
CHINESE JOURNAL OF OPTOMETRY OPHTHALMOLOGY AND VISUAL SCIENCE
2012年
5期
312-314,316
,共4页
糖尿病视网膜病变%舒血宁注射液%治疗结果
糖尿病視網膜病變%舒血寧註射液%治療結果
당뇨병시망막병변%서혈저주사액%치료결과
Diabetic retinopathy%Shuxuening injection%Therapeutic outcome
目的 观察舒血宁注射液治疗单纯性糖尿病视网膜病变的疗效.方法 前瞻性随机病例对照研究.56例1～3期糖尿病视网膜病变的患者随机分为对照组和治疗组,每组28例,对照组只给予口服肠溶阿司匹林片100 mg,1次/d.治疗组在服用阿司匹林的基础上加用舒血宁注射液静滴20 ml,次,1次/d,两组疗程均为4周.通过测定空腹血糖和餐后2 h血糖、检查视力及荧光眼底血管造影观察评价疗效,治疗前后数据比较采用重复测量检验方法,两组间比较采用成组t检验,治疗有效率的比较采用x2检验.结果 与治疗前比较,两组治疗后视力均显著提高,差异有统计学意义(t=0.52,P＜0.05;t=-4.66,P＜0.01),4周后治疗组视力高于对照组明显,差异有统计学意义(t=-2.57,P＜0.05).与治疗前比较,治疗组和对照组治疗后视网膜微血管瘤数均显著减少,差异有统计学意义(t=4.47,P＜0.05,t=4.35,P＜0.05),4周后治疗组视网膜微血管瘤较对照组显著减少,差异有统计学意义(t=-3.42,P＜0.01)；与治疗前比较,治疗组和对照组治疗后出血面积较治疗前均显著减少,差异有统计学意义(t=-4.17,P＜0.01;t=-3.87,P＜0.05);4周后两组出血面积比较,差异无统计学意义.结论 舒血宁注射液治疗单纯性糖尿病性视网膜病变有一定疗效.
目的 觀察舒血寧註射液治療單純性糖尿病視網膜病變的療效.方法 前瞻性隨機病例對照研究.56例1～3期糖尿病視網膜病變的患者隨機分為對照組和治療組,每組28例,對照組隻給予口服腸溶阿司匹林片100 mg,1次/d.治療組在服用阿司匹林的基礎上加用舒血寧註射液靜滴20 ml,次,1次/d,兩組療程均為4週.通過測定空腹血糖和餐後2 h血糖、檢查視力及熒光眼底血管造影觀察評價療效,治療前後數據比較採用重複測量檢驗方法,兩組間比較採用成組t檢驗,治療有效率的比較採用x2檢驗.結果 與治療前比較,兩組治療後視力均顯著提高,差異有統計學意義(t=0.52,P＜0.05;t=-4.66,P＜0.01),4週後治療組視力高于對照組明顯,差異有統計學意義(t=-2.57,P＜0.05).與治療前比較,治療組和對照組治療後視網膜微血管瘤數均顯著減少,差異有統計學意義(t=4.47,P＜0.05,t=4.35,P＜0.05),4週後治療組視網膜微血管瘤較對照組顯著減少,差異有統計學意義(t=-3.42,P＜0.01)；與治療前比較,治療組和對照組治療後齣血麵積較治療前均顯著減少,差異有統計學意義(t=-4.17,P＜0.01;t=-3.87,P＜0.05);4週後兩組齣血麵積比較,差異無統計學意義.結論 舒血寧註射液治療單純性糖尿病性視網膜病變有一定療效.
목적 관찰서혈저주사액치료단순성당뇨병시망막병변적료효.방법 전첨성수궤병례대조연구.56례1～3기당뇨병시망막병변적환자수궤분위대조조화치료조,매조28례,대조조지급여구복장용아사필림편100 mg,1차/d.치료조재복용아사필림적기출상가용서혈저주사액정적20 ml,차,1차/d,량조료정균위4주.통과측정공복혈당화찬후2 h혈당、검사시력급형광안저혈관조영관찰평개료효,치료전후수거비교채용중복측량검험방법,량조간비교채용성조t검험,치료유효솔적비교채용x2검험.결과 여치료전비교,량조치료후시력균현저제고,차이유통계학의의(t=0.52,P＜0.05;t=-4.66,P＜0.01),4주후치료조시력고우대조조명현,차이유통계학의의(t=-2.57,P＜0.05).여치료전비교,치료조화대조조치료후시망막미혈관류수균현저감소,차이유통계학의의(t=4.47,P＜0.05,t=4.35,P＜0.05),4주후치료조시망막미혈관류교대조조현저감소,차이유통계학의의(t=-3.42,P＜0.01)；여치료전비교,치료조화대조조치료후출혈면적교치료전균현저감소,차이유통계학의의(t=-4.17,P＜0.01;t=-3.87,P＜0.05);4주후량조출혈면적비교,차이무통계학의의.결론 서혈저주사액치료단순성당뇨병성시망막병변유일정료효.
Objective To examine the effects of shuxuening injections for the treatment of simple diabetic retinopathy.Methods This was a prospective randomized controlled study.Fifty-six patients with simple diabetic retinopathy were randomly divided into a control group and a treatment group.Patients in the control group were given 100 mg of enteric-coated aspirin tablets while those in the treatment group were given 20 ml shuxuening intravenous injections,once a day.The treatment period lasted for four weeks.Changes in fasting blood glucose (FBG) and 2h postprandial blood glucose (2hBPG) in the serum were measured regularly,and visual acuity and fluorescent angiography were evaluated.The data were analyzed by repeated measurement test,independent samples t test and chi-Square test.Results Visual acuity increased while areas with retinal capillary bemangiomas and the number of retinal micro-aneurysms significantly in the treatment group compared to the control group (P＜0.05) decreased.These indices improved significantly (P＜0.05) in the treatment group.Conclusion Shuxuening injections for the treatment of simple diabetic retinopathy show specific benefits for the integrity of the eye.
