CAJ | 학술논문

目的研究各级慢性阻塞性肺疾病(COPD)患者在峰值运动时的心肺运动试验(CPET)变化特点.方法对102例稳定期男性COPD患者和31名健康男性做常规肺功能和CPET检测.记录常规肺功能参数包括:用力肺活量(FVC)、用力肺活量占预计值的百分比(FVC％ pred)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值的百分比( FEV1％pred)、一秒率(FEV1/FVC％)、最大通气量占预计值的百分比( MVV％ pred)；CPET参数包括峰值运动时的:功率(peakLoad)、功率占预计值的百分比( peakLoad％ pred)、摄氧量占预计值的百分比(peak (V)O2％pred)、公斤摄氧量(peak (V)O2/kg)、分钟通气量( peak(V)E)、运动心率(peakHR)、氧脉搏(peakO2 pulse).比较各级COPD患者的各项参数与正常对照组的差异.结果轻度COPD组的peakLoad较对照组明显下降(P＜0.05),其余CPET参数则差异无统计学意义.中度COPD组的peakLoad、peakLoad％ pred、peak (V)O2/kg、peak (V) E及peakHR较对照组显著降低,而peak (V) O2％pred与peakO2 pulse较对照组差异无统计学意义.重度COPD组峰值运动时各参数(peakLoad,peakLoad％ pred、peak(V)O2％pred、peak(V)O2/kg、peak(V)E、peakHR、peakO2pulse等)均较对照组显著降低(P＜0.01).结论各级COPD患者在峰值运动时的CPET各项参数变化并不一致,完善CPET参数可对COPD现有的严重程度分级作病情评估的补充,有助于及时全面了解病情,早期发现并发症,并指导后续治疗.
목적 연구각급만성조새성폐질병(COPD)환자재봉치운동시적심폐운동시험(CPET)변화특점.방법 대102례은정기남성COPD환자화31명건강남성주상규폐공능화CPET검측.기록상규폐공능삼수포괄:용력폐활량(FVC)、용력폐활량점예계치적백분비(FVC％ pred)、제1초용력호기용적(FEV1)、제1초용력호기용적점예계치적백분비( FEV1％pred)、일초솔(FEV1/FVC％)、최대통기량점예계치적백분비( MVV％ pred)；CPET삼수포괄봉치운동시적:공솔(peakLoad)、공솔점예계치적백분비( peakLoad％ pred)、섭양량점예계치적백분비(peak (V)O2％pred)、공근섭양량(peak (V)O2/kg)、분종통기량( peak(V)E)、운동심솔(peakHR)、양맥박(peakO2 pulse).비교각급COPD환자적각항삼수여정상대조조적차이.결과 경도COPD조적peakLoad교대조조명현하강(P＜0.05),기여CPET삼수칙차이무통계학의의.중도COPD조적peakLoad、peakLoad％ pred、peak (V)O2/kg、peak (V) E급peakHR교대조조현저강저,이peak (V) O2％pred여peakO2 pulse교대조조차이무통계학의의.중도COPD조봉치운동시각삼수(peakLoad,peakLoad％ pred、peak(V)O2％pred、peak(V)O2/kg、peak(V)E、peakHR、peakO2pulse등)균교대조조현저강저(P＜0.01).결론 각급COPD환자재봉치운동시적CPET각항삼수변화병불일치,완선CPET삼수가대COPD현유적엄중정도분급작병정평고적보충,유조우급시전면료해병정,조기발현병발증,병지도후속치료.
Objective To study the changing characteristics of cardiopulmonary exercise test (CPET) in chronic obstructive pulmonary diseases (COPD) patients who take peak exercises.Methods 102 stable COPD male patients and 31 healthy men uuderwent pulmonary function test and CPET.The parameters of pulmonary function test included FVC,FVC ％ pred,FEV1,FEV1 ％ pred,FEV1/FVC％ and MVV％ pred.The parameters of CPET included peakLoad,peakLoad ％ pred,peak (V) O2 ％ pred,peak (V)O2 /kg,peak (V) E,peakHR and peakO2 pulse.We compared these results between different stages of COPD group and control group.Results There was a significant reduction in peakLoad of patients in mild COPD group in comparison to the control group.The peakLoad,peakLoad％ pred,peak (V) O2/kg,peak (V) E and peakHR of patients in moderate COPD were significantly reduced compared with those in control group,and all the parameters of CPET were significantly reduced in severe COPD group than those in control group.Conclusions The variations of CEPT parameters in peak excising COPD patients were not identical.The perfection of CPET parameters could improve the existing classification of the COPD condition evaluation,as well as helps the doctors to master patients conditions more thoroughly and find complications earlier.It has great significance in the guidance of patients' future treatment.