中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
5期
613-615
,共3页
变应原%荨麻疹%湿疹%鼻炎%哮喘%免疫球蛋白E
變應原%蕁痳疹%濕疹%鼻炎%哮喘%免疫毬蛋白E
변응원%담마진%습진%비염%효천%면역구단백E
Allergens%Urticaria%Eczema%Rhinitis%Asthma%Immunoglobulin E
目的 了解肇庆市城区常见过敏性疾病患者中过敏原的分布特征,为临床疾病诊治和过敏原预防提供可靠的科学依据.方法 采用德国敏筛过敏原检测系统检测18种过敏原特异性IgE(slgE)和总IgE(tIgE)含量,以61名健康体检者为对照,回顾性分析334例常见过敏性疾病患者中过敏原sIgE阳性率和tIgE及其分布差异.结果 334例患者的tIgE和sIgE阳性率分别为70.06%(234例)和68.86%(230例),两项均阳性者为54.19%(181例),显著高于对照组[分别为22.95%(14例)、21.30%(13例)、9.83%(6例),P<0.01];过敏原sIgE检出率以户尘螨最高,为54.49%,屋尘次之,为42.22%.荨麻疹、特别性湿疹、过敏性鼻炎、儿童支气管哮喘这4种过敏性疾病患者血清tIgE和sIgE阳性率均分别高于正常对照组(P<0.01),荨麻疹患者中≥2种过敏原slgE阳性者占38.75%(62/160),特异性湿疹患者中≥2种过敏原sIgE阳性者占34.78%(62/160),过敏性鼻炎患者中≥2种过敏原sIgE阳性者占72.22%(62/160),儿童支气管哮喘中≥2种过敏原slgE阳性者占64.71%(33/51).结论 吸入性过敏原是肇庆市城区导致过敏性疾病最主要的过敏原,以户尘螨,屋尘和蟑螂最为常见;tIgE检测对过敏原存在与否的预测有重要参考价值;过敏原sIgE阳性的检出对过敏性疾病的预防、诊断和治疗有十分重要的意义.
目的 瞭解肇慶市城區常見過敏性疾病患者中過敏原的分佈特徵,為臨床疾病診治和過敏原預防提供可靠的科學依據.方法 採用德國敏篩過敏原檢測繫統檢測18種過敏原特異性IgE(slgE)和總IgE(tIgE)含量,以61名健康體檢者為對照,迴顧性分析334例常見過敏性疾病患者中過敏原sIgE暘性率和tIgE及其分佈差異.結果 334例患者的tIgE和sIgE暘性率分彆為70.06%(234例)和68.86%(230例),兩項均暘性者為54.19%(181例),顯著高于對照組[分彆為22.95%(14例)、21.30%(13例)、9.83%(6例),P<0.01];過敏原sIgE檢齣率以戶塵螨最高,為54.49%,屋塵次之,為42.22%.蕁痳疹、特彆性濕疹、過敏性鼻炎、兒童支氣管哮喘這4種過敏性疾病患者血清tIgE和sIgE暘性率均分彆高于正常對照組(P<0.01),蕁痳疹患者中≥2種過敏原slgE暘性者佔38.75%(62/160),特異性濕疹患者中≥2種過敏原sIgE暘性者佔34.78%(62/160),過敏性鼻炎患者中≥2種過敏原sIgE暘性者佔72.22%(62/160),兒童支氣管哮喘中≥2種過敏原slgE暘性者佔64.71%(33/51).結論 吸入性過敏原是肇慶市城區導緻過敏性疾病最主要的過敏原,以戶塵螨,屋塵和蟑螂最為常見;tIgE檢測對過敏原存在與否的預測有重要參攷價值;過敏原sIgE暘性的檢齣對過敏性疾病的預防、診斷和治療有十分重要的意義.
목적 료해조경시성구상견과민성질병환자중과민원적분포특정,위림상질병진치화과민원예방제공가고적과학의거.방법 채용덕국민사과민원검측계통검측18충과민원특이성IgE(slgE)화총IgE(tIgE)함량,이61명건강체검자위대조,회고성분석334례상견과민성질병환자중과민원sIgE양성솔화tIgE급기분포차이.결과 334례환자적tIgE화sIgE양성솔분별위70.06%(234례)화68.86%(230례),량항균양성자위54.19%(181례),현저고우대조조[분별위22.95%(14례)、21.30%(13례)、9.83%(6례),P<0.01];과민원sIgE검출솔이호진만최고,위54.49%,옥진차지,위42.22%.담마진、특별성습진、과민성비염、인동지기관효천저4충과민성질병환자혈청tIgE화sIgE양성솔균분별고우정상대조조(P<0.01),담마진환자중≥2충과민원slgE양성자점38.75%(62/160),특이성습진환자중≥2충과민원sIgE양성자점34.78%(62/160),과민성비염환자중≥2충과민원sIgE양성자점72.22%(62/160),인동지기관효천중≥2충과민원slgE양성자점64.71%(33/51).결론 흡입성과민원시조경시성구도치과민성질병최주요적과민원,이호진만,옥진화장랑최위상견;tIgE검측대과민원존재여부적예측유중요삼고개치;과민원sIgE양성적검출대과민성질병적예방、진단화치료유십분중요적의의.
Objective To investigate the distributional characteristics of anaphylactogens in common patients with allergic diseases and provide scientific basis for its treatment and prevention in Zhaoqing. Methods U-sing the German screen allergens quantitative detection system to determinate 18 kinds of allergen-specific IgE (sIgE) and total IgE (tIgE) levels. Of 61 healthy persons as control,retrospectively analyze of anaphylactogen sIgE and tIgE positive rate and their distribution difference in 334 patients with common allergic diseases. Results Three hundred and thirty-four cases of patients, total IgE and sIgE positive rates were 70.06% and 68. 86% , both were positive in 54. 19% , significantly higher than the control group (P <0. 01). With total IgE positive to predict the risk of positive sIgE detection for 78.70%. In the detection rate of allergen sIgE to household dust mites up 54.49% , 42. 22% followed by house dust, tIgE and sIgE positive rates were higher than the control group (P <0. 01) . In urticaria patients, two or more sIgE antibody positive rate was 38. 75% , two or more sIgE antibody was 34.78% , In allergic rhinitis patients, two or more sIgE antibody was 72. 22% , two or more sIgE antibody positive rate was 64.71%. Conclusions Aeroallergens are the most important allergen cause of allergic diseases, and the most common allergens are household dust mites, house dust and cockroaches in Zhaoqing City. TlgE has important reference value to predict the existence probability of allergens. Allergen sIgE positive detection has agreat significance for the prevention, diagnosis and treatment of allergic diseases.
