中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
1期
68-70
,共3页
尘肺%粉防己碱%支气管肺泡灌洗%转化生长因子β
塵肺%粉防己堿%支氣管肺泡灌洗%轉化生長因子β
진폐%분방기감%지기관폐포관세%전화생장인자β
Pneumoconiosis%TETRANDRINE%Bronchoalveolar,Transforming growth factor beta
目的 探讨汉防己甲素联合大容量肺灌洗治疗尘肺病的疗效.方法 选取34例尘肺患者随机分为汉防己甲素药物治疗组(药物组)和汉防己甲素+大容量肺灌洗治疗组(综合组),每组17例,选取17例门诊体检年龄匹配的健康工人作为对照组.测定治疗前和治疗后血清中转化生长因子-β1(TGF-31)及血清中Ⅲ型前胶原肽(PⅢP)的含量,观察治疗前后临床症状,肺功能改善情况.结果 药物组和综合组尘肺患者的临床症状好转,肺功能改善,药物组和综合组治疗后患者的肺活量(FVC)、第1秒用力呼气量(FEVL0)、FEV10/FVC、最大通气量(MVV)明显高于治疗前,综合组明显高于药物组,差异有统计学意义(P＜0.05).综合组和药物组尘肺病患者治疗前后血清中TGF-β1及PⅢP水平均高于对照组,差异有统计学意义(P＜0.05).治疗后药物组和综合组血清TGF-β1水平及PⅢP水平低于治疗前,综合组患者血清TGF-β1水平及PⅢP水平低于药物组,差异有统计学意义(P＜0.05).结论 汉防己甲素联合大容量全肺灌洗治疗尘肺对改善尘肺病患者的临床症状和肺功能有较好疗效,能降低尘肺患者血清中TGF-β1及PⅢP水平.
目的 探討漢防己甲素聯閤大容量肺灌洗治療塵肺病的療效.方法 選取34例塵肺患者隨機分為漢防己甲素藥物治療組(藥物組)和漢防己甲素+大容量肺灌洗治療組(綜閤組),每組17例,選取17例門診體檢年齡匹配的健康工人作為對照組.測定治療前和治療後血清中轉化生長因子-β1(TGF-31)及血清中Ⅲ型前膠原肽(PⅢP)的含量,觀察治療前後臨床癥狀,肺功能改善情況.結果 藥物組和綜閤組塵肺患者的臨床癥狀好轉,肺功能改善,藥物組和綜閤組治療後患者的肺活量(FVC)、第1秒用力呼氣量(FEVL0)、FEV10/FVC、最大通氣量(MVV)明顯高于治療前,綜閤組明顯高于藥物組,差異有統計學意義(P＜0.05).綜閤組和藥物組塵肺病患者治療前後血清中TGF-β1及PⅢP水平均高于對照組,差異有統計學意義(P＜0.05).治療後藥物組和綜閤組血清TGF-β1水平及PⅢP水平低于治療前,綜閤組患者血清TGF-β1水平及PⅢP水平低于藥物組,差異有統計學意義(P＜0.05).結論 漢防己甲素聯閤大容量全肺灌洗治療塵肺對改善塵肺病患者的臨床癥狀和肺功能有較好療效,能降低塵肺患者血清中TGF-β1及PⅢP水平.
목적 탐토한방기갑소연합대용량폐관세치료진폐병적료효.방법 선취34례진폐환자수궤분위한방기갑소약물치료조(약물조)화한방기갑소+대용량폐관세치료조(종합조),매조17례,선취17례문진체검년령필배적건강공인작위대조조.측정치료전화치료후혈청중전화생장인자-β1(TGF-31)급혈청중Ⅲ형전효원태(PⅢP)적함량,관찰치료전후림상증상,폐공능개선정황.결과 약물조화종합조진폐환자적림상증상호전,폐공능개선,약물조화종합조치료후환자적폐활량(FVC)、제1초용력호기량(FEVL0)、FEV10/FVC、최대통기량(MVV)명현고우치료전,종합조명현고우약물조,차이유통계학의의(P＜0.05).종합조화약물조진폐병환자치료전후혈청중TGF-β1급PⅢP수평균고우대조조,차이유통계학의의(P＜0.05).치료후약물조화종합조혈청TGF-β1수평급PⅢP수평저우치료전,종합조환자혈청TGF-β1수평급PⅢP수평저우약물조,차이유통계학의의(P＜0.05).결론 한방기갑소연합대용량전폐관세치료진폐대개선진폐병환자적림상증상화폐공능유교호료효,능강저진폐환자혈청중TGF-β1급PⅢP수평.
Objective To study the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage.Methods Choose 34 confirmed pneumoconiosis patients as drug treatment group and complex treatment group,and 17 tested workers as control group.Collected the content of TGF-31 and P Ⅲ P which in these three investigated groups.Results Drug treatment group and complex treatment group of patients improved the clinical symptoms and lung function Compared with Pretreatment,the FVC、FEV10、FEV10/FVC、MVV was obviously higher than those before treatment(P＜0.05).Complex treatment group than in the drug treatment group increased more significantly(P＜0.05).The level of TGF-β1 and P Ⅲ P was reduced after complex treatment(P＜0.05).Moreover,the level of TGF-β1 and PⅢP in these patients are lower than in those patients treated with tetrandrine combined with whoie lung lavage(P＜0.05).Conclusion Tetrandrine combined with whole-lung lavage could significantly retard the development of pneumoconiosis by lessening the TGF-β1and PⅢP in serum.
