CAJ | 학술논문

目的:探讨在氟18-脱氧葡萄糖(~(18)F-fluorodeoxyglucose,~(18)F-FDG)PET /CT(positron emission tomography/computed tomography)显像诊断多发性骨髓瘤(multiple myeloma,MM)的价值.材料和方法:回顾性分析2005-08～2009-06经骨髓穿刺或病理活检证实的31例多发性骨髓瘤患者的PET/CT影像特征.结果:MM18F-FDG PET/CT表现出一定特征,大致可分为:①骨质破坏型(28例),表现为不同程度骨质破坏,而无骨髓外脏器侵犯,代谢不同程度活跃,最大标准化摄取值(SUVmax)介于2.5～15.4,平均标准化摄取值(SUV_(avg))介于2.0～11.3;②髓外侵犯型(2例),除骨质不同程度破坏外,另有髓外脏器(肝脏、脾脏及淋巴结等)侵犯,代谢均有不同程度活跃,SUV_(max)介于2.2～8.3,SUV_(avg)介于1.7～6.5;③骨髓弥漫型(1例),全身骨髓弥漫代谢活跃,SUVmax为13.4,SUVavg为8.8,但未见明显骨质破坏.结论:~(18)F-FDG PET/CT能较准确显示MM的病灶形态、范围及肿瘤活性,为MM的诊断和准确分期提供帮助.个别需与溶骨型多发骨转移癌及骨淋巴瘤鉴别.
목적:탐토재불18-탈양포도당(~(18)F-fluorodeoxyglucose,~(18)F-FDG)PET /CT(positron emission tomography/computed tomography)현상진단다발성골수류(multiple myeloma,MM)적개치.재료화방법:회고성분석2005-08～2009-06경골수천자혹병리활검증실적31례다발성골수류환자적PET/CT영상특정.결과:MM18F-FDG PET/CT표현출일정특정,대치가분위:①골질파배형(28례),표현위불동정도골질파배,이무골수외장기침범,대사불동정도활약,최대표준화섭취치(SUVmax)개우2.5～15.4,평균표준화섭취치(SUV_(avg))개우2.0～11.3;②수외침범형(2례),제골질불동정도파배외,령유수외장기(간장、비장급림파결등)침범,대사균유불동정도활약,SUV_(max)개우2.2～8.3,SUV_(avg)개우1.7～6.5;③골수미만형(1례),전신골수미만대사활약,SUVmax위13.4,SUVavg위8.8,단미견명현골질파배.결론:~(18)F-FDG PET/CT능교준학현시MM적병조형태、범위급종류활성,위MM적진단화준학분기제공방조.개별수여용골형다발골전이암급골림파류감별.
Purpose To investigate the diagnostic value of ~(18)F-flurorodeoxyglucose (~(18)F-FDG) PET/CT (positron emission tomography/computed tomography) on multiple myeloma.Materials and Method ~(18)FDG PET/CT imaging findings were retrospectively analyzed in 31cases with multiple myeloma proved by bone marrow aspiration or biopsy from August 2005 to June 2009. Results The PET/CT imaging characteristics were categorized into three types: ① osseous destruction (n=28): Osseous destruction with active metabolism was found in this type combined with no extramedullary organs involvement. The SUV_(max) ranged from 2.5 to 15.4, and the SUV_(arg) ranged from 2.0 to 11.3. ② Extramedullary organ involvement (n=2): Besides osseous destruction, extramedullary organs involvement were detected in this type demonstrating active metabolism in varying degrees. The SUV_(max) ranged from 2.2 to 8.3 and the SUV_(avg) ranged from 1.7 to 6.5. ③ Diffuse bone marrow infiltration (n=1): Diffuse hypermetabolism without osseous destruction was found in the whole body bone marrow with the SUV_(max) of 13.4 and SUV_(avg) of 8.8.Conclusions ~(18)FDG PET/CT can accurately demonstrate the morphology, extent and activity of multiple myeloma, thus facilitating the clinical staging, whereas multiple osteolytic osseous metastases and osseous lymphoma should be excluded for certain cases.