CAJ | 학술논문

目的观察和评价复方乌骨藤汤治疗晚期非小细胞肺癌的临床疗效和毒副作用.方法 84例晚期非小细胞肺癌患者均经病理组织学检查确诊.复方乌骨藤汤每日3次,口服,4周为1个周期,共治疗2个周期.结果 84例患者均可评价,完全缓解(CR)16例,部分缓解(PR)31例,稳定(SD)24例,恶化(PD)13例,患者的近期有效率56.0%,疾病进展时间(TTP)5.4个月,中位生存期11.2个月,1年生存率71.4%.主要毒副作用为个别患者血红蛋白减少,血小板减少和心电图异常,但均可以耐受.结论复方乌骨藤汤治疗晚期非小细胞肺癌有较好的临床疗效,毒副作用比较轻,患者均可以耐受,可改善患者的生存质量,延长生存时间.
목적 관찰화평개복방오골등탕치료만기비소세포폐암적림상료효화독부작용.방법 84례만기비소세포폐암환자균경병리조직학검사학진.복방오골등탕매일3차,구복,4주위1개주기,공치료2개주기.결과 84례환자균가평개,완전완해(CR)16례,부분완해(PR)31례,은정(SD)24례,악화(PD)13례,환자적근기유효솔56.0%,질병진전시간(TTP)5.4개월,중위생존기11.2개월,1년생존솔71.4%.주요독부작용위개별환자혈홍단백감소,혈소판감소화심전도이상,단균가이내수.결론 복방오골등탕치료만기비소세포폐암유교호적림상료효,독부작용비교경,환자균가이내수,가개선환자적생존질량,연장생존시간.
Objective To observe and evaluate the clinical effect and toxic and side reactions of the compound wuguteng decoction in patients with advanced non-small cell lung cancer. Methods The selection of 84 eligible patients were given oral compound wuguteng decoction 3 times per day for 2 therapeutic cycles,each cycles howing 4 weeks.Results All the cases were evaluable for efficacy, among the 84 cases, there were 16 cases of CR, 31 cases of PR, 24 cases of SD and 13 cases of PD. The recent effective rate was 56.0%. Median time to progerssion TTP was 5.4 months, median survival time was 11.2 months, and one yerar survival rate was 71.4%. The major toxic and side reaction included the decrease of hmoglobin, thrombocytopenia and electrocardiogram abnormality in a few cases.All the side effects could be tolerated by the patients.Conclusion The compound wuguteng decoction which is effective in the treatment of advanced non-small cell lung cancer with moderate side effects and safety in clinical practice, can improve the life(QOL) quality and increase the survival time of the patients.