中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2008年
1期
16-20
,共5页
精神分裂症%儿茶酚O-甲基转移酶%多态性,单核苷酸%利哌立酮
精神分裂癥%兒茶酚O-甲基轉移酶%多態性,單覈苷痠%利哌立酮
정신분렬증%인다분O-갑기전이매%다태성,단핵감산%리고립동
Schizophrenia%Catechol O-methyltransferase%Polymorphism,single nucleotide%Risperidone
目的 分析利培酮治疗首次发病(以下简称首发)的精神分裂症患者疗效与儿茶酚胺氧位甲基转移酶(COMT)基因多态性的关联,探讨利培酮疗效的敏感基因.方法 对203例首发精神分裂症患者给予利培酮治疗8周(2～8 ms/d),分别于治疗前和治疗第2～8周末采用阳性和阴性症状量表(PANSS)评分,以减分率评定疗效.并采用限制性片段长度多态技术和序列特异性引物聚合酶链反应技术测定基因型.对痊愈组(29例)、进步组(153例)及无效组(21例)精神分裂症患者与COMT基因单核苷酸多态位点(SNPs)进行关联分析.结果 COMT基因3种多态性基因型及基因频率在利培酮不同疗效患者组间分布差异均无统计学意义(P均＞0.05).COMT的3个单核苷酸多态位点单体型分析,利培酮治疗痊愈组与进步组、有效组与无效组间的差异无统计学意义(P＞0.05).结论 COMT基因可能不是首发精神分裂症患者抗精神病药利培酮的疗效敏感基因.
目的 分析利培酮治療首次髮病(以下簡稱首髮)的精神分裂癥患者療效與兒茶酚胺氧位甲基轉移酶(COMT)基因多態性的關聯,探討利培酮療效的敏感基因.方法 對203例首髮精神分裂癥患者給予利培酮治療8週(2～8 ms/d),分彆于治療前和治療第2～8週末採用暘性和陰性癥狀量錶(PANSS)評分,以減分率評定療效.併採用限製性片段長度多態技術和序列特異性引物聚閤酶鏈反應技術測定基因型.對痊愈組(29例)、進步組(153例)及無效組(21例)精神分裂癥患者與COMT基因單覈苷痠多態位點(SNPs)進行關聯分析.結果 COMT基因3種多態性基因型及基因頻率在利培酮不同療效患者組間分佈差異均無統計學意義(P均＞0.05).COMT的3箇單覈苷痠多態位點單體型分析,利培酮治療痊愈組與進步組、有效組與無效組間的差異無統計學意義(P＞0.05).結論 COMT基因可能不是首髮精神分裂癥患者抗精神病藥利培酮的療效敏感基因.
목적 분석리배동치료수차발병(이하간칭수발)적정신분렬증환자료효여인다분알양위갑기전이매(COMT)기인다태성적관련,탐토리배동료효적민감기인.방법 대203례수발정신분렬증환자급여리배동치료8주(2～8 ms/d),분별우치료전화치료제2～8주말채용양성화음성증상량표(PANSS)평분,이감분솔평정료효.병채용한제성편단장도다태기술화서렬특이성인물취합매련반응기술측정기인형.대전유조(29례)、진보조(153례)급무효조(21례)정신분렬증환자여COMT기인단핵감산다태위점(SNPs)진행관련분석.결과 COMT기인3충다태성기인형급기인빈솔재리배동불동료효환자조간분포차이균무통계학의의(P균＞0.05).COMT적3개단핵감산다태위점단체형분석,리배동치료전유조여진보조、유효조여무효조간적차이무통계학의의(P＞0.05).결론 COMT기인가능불시수발정신분렬증환자항정신병약리배동적료효민감기인.
Objective To analyze the correlation between therapeutic effect of antipsychotic agent risperidone and catechol-O-methyltransferase(COMT)gene polymorphisms in first-episode schizophrenics,to further study the mechanisms of psychiatric symptoms,and to identify genes sensitive to risperidone medication.Methods 203 first-episode schizophrenics were treated with risperidone(2～8 ms/day)for 8 weeks. Reduction rate in PANSS total score from baseline to week 8 Was used for efiectiveness evaluation.Patients were divided into 3 groups based on reduction rate of PANSS total score,i.e.,remitted (≥75%,n=29),improved(75%～25%,n=153)and unresponsive(≤25%,n=21).Restriction fragment length polymorphism analysis as well as sequence-special primers PCR amplification technique were used to determine the genotypes.Results There Was on statistically significant difference in the 3 COMT polymorphism genotypes as well as allele frequency between the 3 schizophrenic groups with different responsiveness to risperidone(P>0.05).Haplotype analysis of the 3 COMT single nucleotide polymorphisms showed no statistically significant difference among remitted group,improved group and unresponsive group.Condusions COMT gene is unlikely a sensitive gene determining the therapeutic effect of antipsychotic agent risperidone in schizophrenia.
